沈萍萍 教授
博士生导师
办公电话:025-89686635
联系地址:南京大学生命科学学院
邮政编码:210023
电子邮件:ppshen@nju.edu.cn
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沈萍萍 教授
基本资料 | 详细资料
导师资格
博士生导师
学术兼职
中国免疫学学会理事,自由基生物学与医学学会理事,中国检测监测联盟理事,江苏省细胞与发育生物学学会理事,江苏省分子医学生物技术重点实验室学术委员会委员,教育部教学指导委员会委员
Sci signaling, Sci rep,J Mol Med、Free radical Bio. Med、Antioxid Redox Sign等SCI刊物审稿人。
研究方向

医药生物技术国家重点实验室 PI,南京大学模式动物研究中心PI。主要从事肿瘤分子免疫学研究,以肿瘤相关巨噬细胞功能重编程为切入点,研究肿瘤微环境的炎性调控及相关信号转导机制,同时研发细胞免疫治疗相关新技术。

入选教育部新世纪优秀人才计划;自然科学基金委创新研究团队骨干之一。主持多项国家、省、部级科研项目;

获得多项科研、教学奖励,获教育部优秀博士生导师提名奖及江苏省优秀博士生导师;在国际一流刊物发表多篇学术论文,并有多项已授权专利技术。

研究方向: 肿瘤分子免疫学,主要课题内容如下:

1. 肿瘤微环境免疫调控
2. 干细胞分化及细胞免疫治疗

Our research interests are focused on the functional regulation of tumor associated macrophages (TAMs)in tumor microenvironment because of their central roles in the development and progression of cancer. A major focus of our group has been to determine the new functional features of TAMs and to explore  the possible mechanisms. In collaboration with Nanjing Gulou Hospital,we have been developing the platform for modifying the structures of surface molecules on TAMs and CAR-T for future clinical application, as well as building up the MSCs therapeutic strategy in leukemia treatment.




3. 临床分子诊断技术

We are collaborating with clinical colleagues to develop the novel technologies for analyzing genes and molecules which are associated with human diseases,particularly cancer. We have established a new, sensitive approach for nucleic aciddetection, which is to be used to detect DNA or RNA with no need for amplification,hereby, revealing the actual number of live viruses. We are also working on antigen modification and antibody production. Currently, we have been trying to apply the novel materials to the test system for improving the detection properties of clinical diagnosis.




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