吴旭东 副教授
 
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吴旭东 副教授
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研究方向

隶属于南京大学生命科学院,医药生物技术国家重点实验室,长期从事炎症发病机制及药物干预的相关工作。承担2项国家自然科学基金的资助(Nos. 81273569Nos. 81001465),以及1项江苏省自然科学基金的研究(BK2012726)。以第一作者或通讯作者在Gastroenterology, Hepatology, Biochem Pharmacol等高影响因子的杂志发表多篇研究论文。获得过南京市优秀论文一等奖(2010年,排名第一)和美国ASBMB颁发的Travel Award2009年,唯一获奖人)

主要研究方向:
1、
巨噬细胞炎症小体和极化机制
2、内质网应激和线粒体途径介导的细胞损伤。

大学开始受教育经历

2006/12-2009/08美国弗吉尼亚联邦大学医学院,免疫与微生物学,联合培养博士

2003/09-2009/08中国药科大学,分子药理学,博士

1998/09-2003/06中国药科大学,药理学,本科


研究工作经历

2011/12-至今,南京大学生命科学院,医药生物技术国家重点实验室,副教授,硕导。

2009/08-2011/11,南京大学生命科学院,医药生物技术国家重点实验室,讲师。


科研成果

获奖情况:

2010年获得由南京市政府颁发的南京市第八届自然科学优秀学术论文奖,题目为“Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways.”获奖者为:吴旭东,张陆勇,尚靖,王涛,王翠芬,严明,江振洲。

Xudong Wu, Travel Award, The American Society for Biochemistry and Molecular Biology, 2009, New Orleans, LA.

发表的相关论文:1.Lili Feng, Pingping Song, Hang Zhou, Ang Li, Yuxiang Ma, Xiong Zhang, Hailiang Liu; Ge Xu; Yang Zhou; Xuefeng Wu; Yan Shen; Yang Sun; Xudong Wu*; Qiang Xu*.Pentamethoxyflavanone regulates macrophage polarization and ameliorates sepsis in mice. Biochem Pharmacol.Available online 4 March 2014, doi: 10.1016/j.bcp.2014.02.016

2.Hang Zhou, Xudong Wu*, Ang Li, Lili Feng, Zhe Gao, Xiong Zhang, YuxiangMa, Yang Sun, Yan Shen, Xuefeng Wu, Qiang Xu*Berberine ameliorates insulin resistance via preventing fatty acid-induced NLRP3 inflammasome activation and triggering autophagy of adipose tissue macrophages.Biochem Pharmacol.2014. (revised)

3.Xudong Wu, Lixin Sun, Weibin Zha, Elaine Studer, Li Chen, Phillip B. Hylemon,William M. Pandak Jr,Arun J. Sanyal, Luyong Zhang, Guangji Wang, Jie Chen, Jianying Wang, Huiping Zhou*. HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in intestrinal epithelial cells.Gastroenterology 2010; 138 (1): 197-209.

4.Xudong Wu, Luyong Zhang, Emily Gurley, Elaine Studer, Jing Shang, Tao Wang, Cuifen Wang, Ming Yan, Zhenzhou Jiang, Phillip B. Hylemon, Arun J. Sanyal, William M. Pandak Jr, Huiping Zhou*. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways.Hepatology 2008; 47(6):1905-1915.

5.Yun Wang, Luyong Zhang, Xudong Wu, Emily C. Gurley, Elaine Kennedy, Phillip B. Hylemon, William M. Pandak, Arun J. Sanyal, Huiping Zhou*. The role of CCAAT enhancer-binding protein homologous protein in human immunodeficiency virus protease-inhibitor–induced hepatic lipotoxicity in mice. Hepatology. 2013 Mar; 57(3):1005-16. doi: 10.1002/hep.26107.

6.HU Ling-Na, FANG Xian-Ying, LIU Hai-Liang, GAO Zhe, WU Xue-Feng, SUN Yang, WU Xu-Dong*, XU Qiang*. Protective effects of 18β-glycyrrhetinic acid on LPS-induced injury in intestinal epithelial cells. Chinese Journal of Natural Medicines. 2013, 11(1): 00240029.

7.YI Hong-Wei, MA Yu-Xiang, WANG Xiao-Ning, LU Jian, CAO Wei, WU Xu-Dong*. Ethanol promotes saturated fatty acid-induced hepatoxicity through ERstress response. Chinese Journal of Natural Medicines.2014. (accepted)

8.Lu Fan, Lingna Hu, Baofang Yang, Xianying Fang, Zhe Gao, Wanshuai Li, Yang Sun, Yan Shen, Xuefeng Wu, Yongqian Shu, Yanhong Gu, Xudong Wu*, Qiang Xu*. ErlotinibPromotes Endoplasmic Reticulum Stress-mediated Injury in Intestinal Epithelium. Toxicol Appl Pharmacol.2014. (accepted)

9.Li Chen, Sirikalaya Jarujaron, Xudong Wu, Lixin Sun, Weibin Zha, Guang Liang, Xuan Wang, Emily C. Gurley, Elaine J. Studer, Phillip B. Hylemon, William M. Pandak Jr., Luyong Zhang, Guangji Wang, Xiaokun Li, Paul Dent, Huiping Zhou*. HIV Protease Inhibitor Lopinavir-induced TNF-α and IL-6 Expression is Coupled to the Unfolded Protein Response and ERK Signaling Pathways in Macrophages. BiochemPharmacol 2009; 78(1): 70-77.

10.Xuefeng Wu, Jingjing Fan, Zijun Ouyang, Rui Ning, Wenjie Guo, Yan Shen, Xudong Wu, Yan Sun, Xu Q*.Tupistra chinensis extract attenuates murine fulminant hepatitis with multiple targets against activated T lymphocytes.J Pharm Pharmacol. 2014 Mar; 66(3):453-65. doi: 10.1111/jphp.12176.


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