毕艳 教授

毕艳，主任医师，教授，博士生导师，南京大学医学院附属鼓楼医院副院长兼临床医学研究院院长。中华医学会糖尿病学分会委员，中华医学会糖尿病学分会肥胖与糖尿病学组副组长，中国康复医学会糖尿病预防与康复专业委会副主任委员，江苏省医学会糖尿病学分会副主任委员，江苏省老年医学学会老年内分泌分会主任委员，中华糖尿病杂志编委。主要致力于糖尿病和肥胖的治疗靶点及临床转化研究，以第一及通讯作者在Cell Metabolism，Diabetes Care, Nature Communications, Journal of Hepatology, Diabetes等杂志发表SCI论著88篇。成果写入国际糖尿病联盟全球糖尿病指南和亚太工作组非酒精性脂肪性肝病指南。在美国糖尿病年会、欧洲糖尿病年会、国际糖尿病联盟西太平洋会议、中华医学会糖尿病学分会全国年会等大会报告30次。主持国家自然科学基金重点项目、科技部国家重点研发计划子课题等科研项目27项。相关研究获中国糖尿病十大研究最具影响力研究奖，江苏医学科技奖一等奖，江苏省医学新技术引进一等奖。担任代谢领域国际一流期刊Diabetes Care等杂志审稿人和Diabetes Obesity &Metabolism编委。入选中华医学会糖尿病学分会杰出青年科学研究者，江苏省医学重点人才，江苏省333高层次人才培养工程第二层次培养对象，江苏省六大人才高峰，南京市有突出贡献中青年专家。

教育经历：

2005.9－2008.7，中山大学，内科学 内分泌与代谢病，博士

2001.8－2004.7，南京大学医学院，内科学 内分泌与代谢病，硕士

1992.9－1998.7，吉林大学，临床医学，学士

工作经历：

2023.11－至今，南京大学医学院附属鼓楼医院临床医学研究院，院长

2022.12－至今，南京大学医学院附属鼓楼医院，副院长

2022.11－至今，南京大学代谢病研究所，所长

2022.3－2023.5，南京大学医学院附属鼓楼医院内分泌科，行政主任

2021.2－至今，南京大学医学院附属鼓楼医院科技处，处长

2016.7－至今，南京医科大学，博士生导师

2015.6－至今，南京大学，博士生导师

2015.3－2022.2，南京大学医学院附属鼓楼医院内分泌科，行政副主任

2016.12－至今，南京大学医学院附属鼓楼医院，主任医师

2012.4－2016.4，南京大学临床医学博士后流动站，博士后

2010.10－2016.11，南京大学医学院附属鼓楼医院，副主任医师

2009.9－2010.9，英国谢菲尔德大学，访问学者

2005.1－2010.9，南京大学医学院附属鼓楼医院，主治医师

1998.8－2004.12，南京大学医学院附属鼓楼医院，住院医师

糖尿病，肥胖，脂肪肝

1.2019年，中华医学会糖尿病学分会 委员

2.2019年，中华医学会糖尿病学分会肥胖与糖尿病学组 副组长

3.2022年，中国康复医学会糖尿病预防与康复专业委员会 副主任委员

4.2021年，中国康复医学会器官移植康复专业委员会 副主任委员

5.2021年，中国女医师协会糖尿病专业委员会 常务委员

6.2018年，中国老年学和老年医学学会老年病学分会干细胞专家委员会 常务委员

7.2019年，中国微循环学会糖尿病与微循环专业委员会 秘书长

8.2018年，中华医学会肠外肠内营养学分会人工智能与营养基础数据协作组 委员

9.2020年，中国老年学和老年医学学会基层慢病防治管理分会 委员

10.2020年，江苏省医学会糖尿病学分会 副主任委员

11.2020年，江苏省医师协会糖尿病专业委员会 副主任委员

12.2021年，江苏省医学会糖尿病学分会肥胖和营养学组 组长

13.2022年，江苏省老年医学学会老年内分泌分会 主任委员

14.2020年，江苏省医学会内分泌学分会 委员

15.2020年，南京医学会内分泌学专科分会 副主任委员

16.2020年，南京糖尿病并发症研究会脑病分会 主任委员

17.2020年，南京医学会内分泌学专科分会社区糖尿病管理学组 组长

科研项目：

1.泌乳素介导营养感应通过神经-内分泌机制调控肝脏脂质代谢稳态的研究，国家自然科学基金重点项目（82030026），2021.01-2025.12，297万元，课题负责人，在研

2.CD9+CD55low脂肪前体细胞介导高脂诱导脂肪组织炎症和2型糖尿病的作用和机制研究，国家自然科学基金面上项目（82270883），2023.01-2026.12，52万元，课题负责人，在研

3.ILC1/ILC2细胞免疫特性在脂肪组织纤维化发生发展中的作用及其机制研究，国家自然科学基金面上项目（81770819），2018.1-2021.12，52万元，课题负责人，结题

4.AMPK在胰岛素抑制SREBP-1c活化而改善骨骼肌脂毒性胰岛素抵抗中的作用机制研究，国家自然科学基金面上项目（81570736），2016.1-2019.12，58万元，课题负责人，结题

5.高脂诱导骨骼肌胰岛素抵抗的分子调控机制研究，国家自然科学基金面上项目（81270906），2013.1-2016.12，65万元，课题负责人，结题

6.SREBP-1c在2型糖尿病骨骼肌胰岛素抵抗及脂毒性中的作用及机制研究，国家自然科学基金青年项目（30800539），2009.1-2011.12，19万元，课题负责人，结题

7.1型糖尿病优化监测与治疗方案的研究及关键新技术推广，子课题“干细胞治疗T1D的临床转化研究”，国家重点研发计划（2017YFC1309605），2017.1-2020.12，239万元，子课题负责人，结题

8.基于人工智能的多模态一体化NASH无创诊断和决策系统的建设，江苏省重点研发专项资金社会发展项目（BE2022666），2022.07-2025.06，50万元，课题负责人，在研

9.基于糖尿病分级诊疗体系的标准化数据建设，江苏省重点研发专项资金社会发展项目（BE2016606），2016.7-2019.6，80万元，课题负责人，结题

10.基于AI精准画像辅助决策的2型糖尿病全程标准化达标管理关键技术应用研究，江苏省重点研发专项资金社会发展项目（BE2023774），2023.07-2026.06，40万元，子课题负责人，在研

11.“十四五”省医学重点学科建设单位，内分泌病学与代谢病学，江苏省“十四五”卫生健康科教能力提升工程（JSDW202201），2021.1-2025.12，120万元，课题负责人，在研

12.肠道菌群与非酒精性脂肪肝的关系及其机制研究，江苏省卫计委十三五“科教强卫工程” 医学重点人才（ZDRCA2016062），2016.1-2020.12，150万元，课题负责人，结题

13.2型糖尿病脂肪细胞功能与GLP-1受体激动剂药物疗效的基础与临床研究，江苏省卫生厅“科教兴卫工程”医学重点人才（RC2011011），2011.1-2015.12，100万元，课题负责人，结题

14.2型糖尿病认知并发症的早期诊断和干预研究，江苏省第十六批“六大人才高峰”高层次人才选拔培养资助项目（YY-086），2020.1-2022.12，4万元，课题负责人，结题

15.利拉鲁肽、恩格列净、或利格列汀对2型糖尿病伴轻度认知功能障碍患者认知脑保护的疗效比较：多中心、随机、平行对照临床研究，2022年度南京鼓楼医院临床研究专项资金项目（重大项目）（2022-LCYJ-ZD-03），2022.07-2027.06，430万元，课题负责人，在研

发表论文：

1. Jin Wang^#, Liang Li^#, Zhou Zhang, Xuhong Zhang, Ye Zhu, Chenyu Zhang, Yan Bi*. Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance. Cell Metab, 2022, 34(9):1264-1279. (通讯作者，IF=31.373，1区)

2. Haiyan Cheng^#, Zhou Zhang^#, Bing Zhang^#, Wen Zhang, Jin Wang, Wenyu Ni, Yingwen Miao, Jiani Liu, Yan Bi*. Enhancement of Impaired Olfactory Neural Activation and Cognitive Capacity by Liraglutide, but not Dapagliflozin or Acarbose, in Patients With Type 2 Diabetes: A 16-Week Randomized Parallel Comparative Study. Diabetes Care, 2022, 45(5):1201-1210. (通讯作者，IF=17.152，1区)

3. Junjie Huang^#, Hanxu Chen, Ning Li, Luoran Shang*, Yan Bi*, Yuanjin Zhao*. Harvesting stem cell exosomes from herringbone microfluidic bioreactor for wound healing. Nano Today, 2023,52:101983. (通讯作者，IF=17.4, 1区)

4. Jiahui Guo^#, Yunru Yu, Yingbo Shen, Xiaoyan Sun*, Yan Bi*, Yuanjin Zhao*. Multiple Bio-Actives Loaded Gellan Gum Microfibers from Microfluidics for Wound Healing. Small, 2023,19(44):e2303887. (通讯作者，IF=13.3, 1区)

5. Da Fang^#, Wenjuan Tang^#, Xiaoyu Zhao, Haixiang Sun, Tianwei Gu*, Yan Bi*. Gender differences in the association of body composition and biopsy-proved nonalcoholic steatohepatitis. Hepatol Int, 2022, 16(2):337-347. (通讯作者，IF=9.029，2区)

6. Haixiang Sun^#, Da Fang^#, Hongdong Wang^#, Jin Wang^#, Yue Yuan, Shanshan Huang, Huayang Ma, Tianwei Gu*, Yan Bi*. The association between visceral adipocyte hypertrophy and NAFLD in subjects with different degrees of adiposity. Hepatol Int, 2023,17(1):215-224. (通讯作者，IF=9.029，2区)

7. Yingwen Miao^#, Jin Wang^#, Bing Zhang^#, Wen Zhang, Xiang Xu, Yingjiao Hou, Qun Ding, Congcong Yu, Zhou Zhang*, Yan Bi*, Dalong Zhu*. Altered brain spontaneous and synchronization activity in latent autoimmune diabetes in adults: A resting-state functional MRI study. Diabetes Metab Res Rev, 2023,39(1):e3587. (通讯作者，IF=8, 2区)

8. Da Fang^#, Hongli Yin^#, Xinlu Ji^#, Haixiang Sun, Xiaoyu Zhao, Yan Bi*, Tianwei Gu*. Low levels of osteocalcin, but not CTX or P1NP, are associated with nonalcoholic hepatic steatosis and steatohepatitis. Diabetes Metab, 2023,49(2):101397. (通讯作者，IF=7.2, 2区)

9. Sai Tian^#, Jiaxuan Jiang^#, Jin Wang, Zhou Zhang, Yingwen Miao, Xinlu Ji, Yan Bi*. Comparison on cognitive outcomes of antidiabetic agents for type 2 diabetes: A systematic review and network meta-analysis. Diabetes Metab Res Rev, 2023,39(7):e3673. (通讯作者，IF=8, 2区)

10. Wenjuan Tang^#, Kang Ge^#, Lei Shen^#, Hongdong Wang, Wenhuan Feng, Xitai Sun, Xuehui Chu, Dalong Zhu, Hongli Yin*, Yan Bi*. Th1 bias of liver mucosal-associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus. Diabetes Metab Res Rev, 2023,39(4):e3620. (通讯作者，IF=8, 2区)

11. Yining Chao^#, Tianwei Gu^#, Zhou Zhang^#, Tianyu Wu, Jin Wang*, Yan Bi*. The role of miRNAs carried by extracellular vesicles in type 2 diabetes and its complications. J Diabetes, 2023,15(10):838-852. (通讯作者，IF=4.5, 2区)

12. Yingwen Miao^#, Bing Zhang^#, Xitai Sun, Xuelin Ma, Da Fang, Wen Zhang, Tianyu Wu, Xiang Xu, Congcong Yu, Yinjiao Hou, Qun Ding, Sijue Yang, Linqing Fu, Zhou Zhang*, Yan Bi*. The presence and severity of NAFLD are associated with cognitive impairment and hippocampal damage. J Clin Endocrinol Metab, 2023,108(12):3239-3249. (通讯作者，IF=5.8, 2区)

13. Qing Ling^#, Lei Shen^#, Wei Zhang, DuoDuo Qu, Hongdong Wang, Bin Wang, Yong Liu, Jing Lu*, Dalong Zhu*, Yan Bi*. Increased plasmablasts enhance T cell-mediated beta cell destruction and promote the development of type 1 diabetes. Mol Med, 2022, 28(1):18. (通讯作者，IF=6.376，2区))

14. Ziwei Zhang^#, Menglian Li^#, Jianjun Wang, Mengsi Liu, Huan Chen, Yuan Lou, Yijie Wang, Qi Sun, Dalong Zhu, Ping Li*, Yan Bi*. Expression and clinical significance of VISTA and PD-L1 in adrenocortical carcinoma. Endocr Relat Cancer, 2022, 29(7):403-413. (通讯作者，IF=5.900，2区)

15. Xiaowen Zhang^#, Chen Han^#, Hongwei Wang, Xinghong Sun, Xin Dou, Xueying He, Di Wu, Shanmei Shen, Dalong Zhu*, Xinlin Zhang*, Yan Bi*. The correlation of the neutrophil-lymphocyte ratio to clinical and imaging parameters in patients with thyroid eye disease. Endocr Connect, 2022, 11(11):e220260. (通讯作者，IF=3.221，3区)

16. Yangyang Xia^#, Chunming Jiang, Jing Lu, Jie Liu, Tianwei Gu*, Yan Bi*. Associations Between Obesity and Kidney Disease in Chinese Men and Women With Type 2 Diabetes: A Retrospective Cohort Study. Can J Diabetes, 2022, 46(1):47-52.e3. (通讯作者，IF=2.774，3区)

17. Fangcen Liu^#, Jielei He^#, Boxun Liu^#, Pengzi Zhang, Hongdong Wang, Xitai Sun, Xuehui Chu, Wenxian Guan, Wenhuan Feng, Yan Bi*, Dalong Zhu*. Association of Omental Adipocyte Hypertrophy and Fibrosis with Human Obesity and Type 2 Diabetes. Obesity (Silver Spring), 2021, 29(6):976-984. (通讯作者，IF=9.298，2区)

18. Yanmei Wang^#, Zhijuan Ge^#, Lei Chen^#, Jun Hu, Wenting Zhou, Shanmei Shen, Dalong Zhu*, Yan Bi*. Risk Prediction Model of Gestational Diabetes Mellitus in a Chinese Population Based on a Risk Scoring System. Diabetes Ther, 2021, 12(6):1721-1734. (通讯作者，IF=3.595，3区)

19. Ning-Jing Zhang^#, Yu-Zhe Fu^#, Xiao-Dong Shan^#, Ning Zhang, Xi-Tai Sun, Xue-Hui Chu, Yan Bi*, Da-Long Zhu*, Wen-Huan Feng*. Are Chinese Patients with Type 2 Diabetes and a Body Mass Index of 27.5-32.5 kg/m² Suitable for Metabolic Surgery? A One-Year Post-Surgery Study. Diabetes Ther, 2021, 12(5):1429-1444. (通讯作者，IF=3.595，3区)

20. Jing Lu^#, Shan-Mei Shen^#, Qing Ling^#, Bin Wang, Li-Rong Li, Wei Zhang, Duo-Duo Qu, Yan Bi*, Da-Long Zhu*. One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study. Stem Cell Res Ther, 2021, 12(1):340. (通讯作者，IF=8.079，2区)

21. Yu Jin^#, Weimin Wang^#, Wei Chen^#, Simin Guo, Chenxi Li, Dalong Zhu, Yan Bi*. Corneal confocal microscopy: A useful tool for diagnosis of small fiber neuropathy in type 2 diabetes. J Diabetes Investig, 2021, 12(12):2183-2189. (通讯作者，IF=3.681，3区)

22. Fangcen Liu^#, Jielei He^#, Ye Zhu^#, Hongdong Wang, Wenhuan Feng, Xitai Sun, Yan Bi*, Dalong Zhu*. Body Adiposity Index Is Predictive of Weight Loss after Roux-en-Y Gastric Bypass. Ann Nutr Metab, 2021, 77(3):168-177. (通讯作者，IF=5.923，3区)

23. Yue Yuan^#, Hongdong Wang, Jielei He, Haixiang Sun, Dalong Zhu, Yan Bi*. Peripheral Administration of NMU Promotes White Adipose Tissue Beiging and Improves Glucose Tolerance. Int J Endocrinol, 2021;2021:6142096. (通讯作者，IF=3.257，3区)

24. Chenxi Li^#, Weimin Wang^#, Wenyu Ni^#, Yu Jin, Simin Guo, Jiewen Jin, Chuhui Chen, Wei Chen, Yan Bi*, Dalong Zhu*. Better Islet Function and Cardiovascular Autonomic Function in Chinese Type 2 Diabetic Patients with Pure Small Fiber Neuropathy than with Mixed Neuropathy. Diabetes Ther, 2021, 12(9):2423-2436. (通讯作者，IF=3.595，3区)

25. Wenyu Ni^#, Zhou Zhang^#, Bing Zhang, Wen Zhang, Haiyan Cheng, Yingwen Miao, Wei Chen, Jiani Liu, Dalong Zhu, Yan Bi*. Connecting Peripheral to Central Neuropathy: Examination of Nerve Conduction Combined with Olfactory Tests in Patients with Type 2 Diabetes. Diabetes Metab Syndr Obes, 2021,14:3097-3107. (通讯作者，IF=3.249，3区)

26. Wang HD^#, Tang WJ, Zhang PZ, Zhang Z, He J, Zhu DL, Bi Y*. Modulation of gut microbiota contributes to effects of intensive insulin therapy on intestinal morphological alteration in high fat-diet treated mice. Acta Diabetol, 2020, 57(4):455-467. (通讯作者，IF=4.28，3区)

27. Jun Hu^#, Zhijuan Ge^#, Qianyue Xu, Shanmei Shen, Yanmei Wang, Dalong Zhu, Yan Bi*. Influence of Fetal Sex on Perinatal Outcomes in Women With Gestational Diabetes Mellitus. Diabetes Metab Res Rev, 2020, 36(3):e3245. (通讯作者，IF=4.876，2区)

28. Lei Yu^#, Haoran Wang^#, Xiaoxue Han, Honghui Liu, Dalong Zhu, Wenhuan Feng*, Jinhui Wu*, Yan Bi*. Oxygen Therapy Alleviates Hepatic Steatosis by Inhibiting Hypoxia-Inducible factor-2α. J Endocrinol, 2020, 246(1):57-67. (通讯作者，IF=4.286，2区)

29. Fangcen Liu^#, Jielei He, Hongdong Wang, Dalong Zhu, Yan Bi*. Adipose Morphology: a Critical Factor in Regulation of Human Metabolic Diseases and Adipose Tissue Dysfunction. Obes Surg, 2020, 30(12):5086-5100. (通讯作者，IF=4.129，2区)

30. Chen C^#, Wang W, Zhou W, Jin J, Chen W, Zhu D, Bi Y*. Nocturnal ventricular arrhythmias are associated with the severity of cardiovascular autonomic neuropathy in type 2 diabetes. J Diabetes, 2019, 11(10):794-801. (通讯作者，IF=3.28，2区)

31. Jin J^#, Wang W^#, Gu T^#, Chen C, Sun J, Chen W, Bi Y*, Zhu D*. Low serum bilirubin levels contribute to the presence and progression of distal symmetrical polyneuropathy in Chinese patients with type 2 diabetes. Diabetes Metab, 2019, 45(1):47-52. (通讯作者，IF=4.731，2区)

32. Feng W^#, Yin T^#, Chu X, Shan X, Jiang C, Wang Y, Qian Y, Zhu D*, Sun X*, Bi Y*. Metabolic effects and safety of Roux-en-Y gastric bypass surgery vs. conventional medication in obese Chinese patients with type 2 diabetes. Diabetes Metab Res Rev, 2019;35(5):e3138. (通讯作者，IF=3.314，2区)

33. Zhang Z^#, Zhang B^#, Wang X^#, Zhang X, Yang QX, Qing Z, Zhang W, Zhu D^#, Bi Y*. Olfactory Dysfunction Mediates Adiposity in Cognitive Impairment of Type 2 Diabetes: Insights From Clinical and Functional Neuroimaging Studies. Diabetes Care, 2019;42(7):1274-1283. (通讯作者，IF=16.019，1区)

34. Wang H^#, Shen L^#, Sun X^#, Liu F^#, Feng W, Jiang C, Chu X, Ye X, Jiang C, Wang Y, Zhang P, Zang M, Zhu D^#, Bi Y*. Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity. Nat Commun, 2019, 10(1):3254. (通讯作者，IF=12.121，1区)

35. Gu T^#, Ma J^#, Zhang Q^#, Zhu L^#, Zhang H, Xu L, Cheng J, Shi B, Li D, Shao J, Sun Z, Zhong S, Bi Y*, Zhu D*. Comparative effect of saxagliptin and glimepiride with a composite endpoint of adequate glycaemic control without hypoglycaemia and without weight gain in patients uncontrolled with metformin therapy: Results from the SPECIFY study, a 48-week, multi-centre, randomized, controlled trial. Diabetes Obes Metab, 2019, 21(4):939-948. (通讯作者，IF=5.900，2区)

36. Tang W^#, Zhang B^#, Wang H, Li M, Wang H, Liu F, Zhu D, Bi Y*. Improved skeletal muscle energy metabolism relates to the recovery of β cell function by intensive insulin therapy in drug naïve type 2 diabetes. Diabetes Metab Res Rev, 2019, 35(7):e3177. (通讯作者，IF=3.314，2区)

37. Xu Q^#, Ge Z^#, Hu J, Shen S, Bi Y*, Zhu D. The Association of gestational weight gain and adverse pregnancy outcomes in women with gestational diabetes mellitus. Endocr Pract, 2019, 25(11):1137-1150. (通讯作者，IF=3.869，2区)

38. Zhang B^#, Shen S^#, Gu T, Hong T, Liu J, Sun J, Wang H, Bi Y*, Zhu D*. Increased circulating conjugated primary bile acids are associated with hyperandrogenism in women with polycystic ovary syndrome. J Steroid Biochem Mol Biol, 2019, 189:171-175. (通讯作者，IF=3.813，2区)

39. Hong T^#, Ge Z^#, Zhang B, Meng R, Zhu D*, Bi Y*. Erythropoietin suppresses hepatic steatosis and obesity by inhibiting endoplasmic reticulum stress and upregulating fibroblast growth factor 21. Int J Mol Med, 2019, 44(2):469-478. (通讯作者，IF=3.098，3区)

40. Liu F^#, Wang H^#, Feng W^#, Ye X, Sun X, Jiang C, Chu X, Zhang P, Jiang C, Wang Y, Zhu D*, Bi Y*. Type 1 innate lymphoid cells are associated with type 2 diabetes. Diabetes Metab, 2019, 45(4):341-346. (通讯作者，IF=4.731，2区)

41. Yuyang Ze^#, Xiaowen Zhang^#, Fei Shao, Lin Zhu, Shanmei Shen*, Dalong Zhu*, Yan Bi*. Active Surveillance of Low-risk Papillary Thyroid Carcinoma: A Promising Strategy Requiring Additional Evidence. J Cancer Res Clin Oncol, 2019, 145(11):2751-2759. (通讯作者，IF=3.656，3区)

42. Ling Q^#, Lu J^#, Li J, Xu Q, Zhu D*, Bi Y*. Risk of beta-cell antoimmunity presence of progression to type 1 diabetes: a systemic review and meta-analysis. J Autoimmu, 2018, 86:9-18. (通讯作者，IF=7.543，2区)

43. Zhang B^#, Wang J^#, Shen S^#, Liu J, Sun J, Gu T, Ye X, Zhu D*, Bi Y*. Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome. Biomed Res Int, 2018, 2018:6869705. (通讯作者，IF=2.197，3区)

44. Zhang P^#, Ge Z^#, Wang H^#, Feng W, Sun X, Chu X, Jiang C, Wang Y, Zhu D*, Bi Y*. Prolactin improves hepatic steatosis via CD36 pathway. J Hepatol, 2018, 68(6):1247-1255. (通讯作者，IF=18.946，1区)

45. Zhang Z^#, Zhang B^#, Wang X^#, Zhang X, Yang QX, Qing Z, Lu J, Bi Y*, Zhu D*. Altered Odor-Induced Brain Activity as an Early Manifestation of Cognitive Decline in Patients with Type 2 Diabetes. Diabetes, 2018, 67(5):994-1006. (通讯作者，IF=7.199，1区)

46. Hong T^#, Ge Z^#, Meng R, Wang H, Zhang P, Tang S, Lu J, Gu T, Zhu D*, Bi Y*. Erythropoietin alleviates hepatic steatosis by activating SIRT1-mediated autophagy. Biochim Biophys Acta, 2018, 1863(6):595-603. (通讯作者，IF=4.402, 2区)

47. Sun J^#, Zhou W^#, Gu T^#, Zhu D, Bi Y*. A retrospective study on association between obesity and cardiovascular risk diseases with aging in Chinese adults. Sci Rep, 2018;8(1):5806. (通讯作者，IF=4.011,3区)

48. Zhang X^#, Shao F^#, Zhu L, Ze Y, Zhu D*, Bi Y*. Cardiovascular and microvascular outcomes of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized controlled cardiovascular outcome trials with trial sequential analysis. BMC Pharmacol Toxicol, 2018, 19(1):58. (通讯作者，IF=2.103, 3区)

49. Tang S^#, Wu W^#, Tang W, Ge Z, Wang H, Hong T, Zhu D*, Bi Y*. Suppression of Rho-kinase 1 is responsible for insulin regulation of the AMPK/SREBP-1c pathway in skeletal muscle cells exposed to palmitate. Acta Diabetol, 2017, 54(7):635-644. (通讯作者，IF=3.126, 3区)

50. Feng W^#, Wang H^#, Zhang P, Gao C, Tao J, Ge Z, Zhu D*, Bi Y*. Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats. Biochim Biophys Acta Gen Subj, 2017, 1861(7):1801-1812. (通讯作者，IF=3.679, 2区)

51. Zhang P^#, Lu J^#, Jing Y^#, Tang S, Zhu D*, Bi Y*. Global Epidemiology of Diabetic Foot Ulceration: A Systematic Review and Meta-Analysis. Ann Med, 2017, 49(2):106-116. (通讯作者，IF=3.007, 2区)

52. Tang W^#, Tang S, Wang H, Ge Z, Zhu D*, Bi Y*. Insulin restores UCP3 activity and decreases energy surfeit to alleviate lipotoxicity in skeletal muscle. Int J Mol Med, 2017, 40(6):2000-2010. (通讯作者，IF=2.784, 2区)

53. Tang W^#, Xu Q^#, Hong T^#, Tong G, Feng W, Shen S, Bi Y*, Zhu D*. Comparative efficacy of anti-diabetic agents on nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized and non-randomized studies. Diabetes Metab Res Rev, 2016, 32(2):200-216. (通讯作者，IF=3.263, 2区)

54. Ge ZJ^#, Zhang PZ^#, Hong T^#, Meng R, Bi Y*, Zhu DL*. Erythropoietin alleviates hepatic insulin resistance via PPARγ-dependent AKT activation. Sci Rep, 2015, 5:17878. (通讯作者，IF=5.228, 3区)

55. Xu W^#, Bi Y^#, Sun ZL^#, Li J, Guo LX, Yang T, Wu G, Shi LX, Feng ZP, Qin L, Guo XH, Luo ZJ, Lu JM, Shan ZY, Yang WY, Ji QH, Yan L, Li H, Yu XF, Li SQ, Zhou ZG, Lv XF, Liang Z, Lin SD, Zeng LY, Yan JH, Ji LN*, Weng JP*. Comparison of the effects on glycaemic control and β-cell function in newly diagnosed type 2 diabetes patients treated with exenatide, insulin or pioglitazone: a multicentre randomized parallel-group trial (the CONFIDENCE study). J Intern Med, 2015, 277(1):137-150. (第一作者，IF=7.803, 1区)

56. Wu WJ^#, Tang SYY^#, Shi JF^#, Yin WW, Cao S, Bu RF, Zhu DL*, Bi Y*. Metformin attenuates palmitic acid-induced insulin resistance in L6 cells through the AMP-activated protein kinase/sterol regulatory element-binding protein-1c pathway. Int J Mol Med, 2015, 35(6):1734-1740. (通讯作者，IF=2.348, 3区)

57. Ge ZJ^#, Zhang PZ^#, Bi Y^#, Li CL^#, Yang HJ, Zhu DL*. Elevated Plasma level of Pigment Epithelium-Derived Factor in type 2 diabetic patients is reduced by metformin treatment in association with weight loss. J Diabetes, 2015, 7(5):740-2. (第一作者，IF=2.5, 2区)

58. Bi Y^#*, Wu WJ^#, Shi JF^#, Liang H^#, Yin WW, Chen YY, Tang SYY, Cao S, Cai MY, Shen SM, Gao Q, Weng JP*, Zhu DL*. Role for sterol regulatory element binding protein-1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription. Diabetologia, 2014;57(3):592-602. (第一作者、通讯作者，IF=6.671, 1区)

59. Bi Y^#, Zhang B^#, Xu W, Yang HJ, Feng WH, Li M, Tong GY, Shen SM, Wang X, Zhu B*, Weng JP*, Zhu DL*. Effects of exenatide, insulin, and pioglitazone on liver fat content and body fat distributions in drug-naive subjects with type 2 diabetes. Acta Diabetol, 2014, 51(5):865-873. (第一作者，IF=3.679, 3区)

60. Li CL^#, Yang HJ^#, Tong GY, Shen SM, Hu Y, Feng WH, Bi Y*, Zhu DL*. Correlations between A1c, fasting glucose, 2h postload glucose, and β-cell function in the Chinese populations. Acta Diabetol, 2014, 51(4):601-608. (通讯作者，IF=3.679, 3区)

61. Bi Y^#, Tong GY^#, Yang HJ^#, Cai MY^#, Ma JH, Liang J, Xin B, Miao H, Peng ZH, Zhu DL*. The effect of metformin on β-cell function in non-obese Chinese subjects with newly diagnosed type 2 diabetes. Diabetes Metab Res Rev, 2013, 29(8):664-672. (第一作者，IF=3.593, 2区)

62. Bi Y^#, Yan JH^#, Tang WL, Yang J, Weng JP*. Prevalence of hypoglycemia by intensive bedside glucose monitoring among hospitalized patients with diabetes mellitus in China. J Diabetes, 2013, 5(3):300-301. (第一作者，IF=2.939, 2区)

63. Bi Y^#, Zeng LY, Zhu DL*, Yan JH, Zhang YH, Tong GY, Mu PW, Shen SM, Hu Y, Yu QQ, Liang H, Weng JP*. Association of β-cell function and insulin sensitivity with fasting and 2h plasma glucose in a large Chinese population. Diabetes Obes Metab, 2012, 14(2):174-180. (第一作者，IF=5.181, 2区)

64. Bi Y^#, Zhu DL^#*, Jing YL, Hu Y, Feng WH, Shen SM, Tong GY, Shen XJ, Yu TT, Song D, Yang DH. Decreased beta cell function and insulin sensitivity contributed to increasing fasting glucose in Chinese. Acta Diabetol, 2012, 49 (Suppl 1):S51-S58. (第一作者，IF=4.631, 3区)

65. Bi Y^#, Li XB, Yang DZ, Hao YT, Liang H, Zhu DL*, Weng JP*. Comparative efficacy and safety of long-acting insulin analogs in patients with type 2 diabetes failing on oral therapy: systemic review and meta-analyses. J Diabetes Invest, 2012, 3(3):283-293. (第一作者，IF=1.861, 3区)

66. Jing YL^#, Sun QM^#, Bi Y^#, Shen SM, Zhu DL*. SLC30A8 polymorphism and type 2 diabetes risk: Evidence from 27 study groups. Nutr Metab Cardiovasc Dis, 2011, 21(6):398-405. (第一作者，IF=3.731, 3区)

67. Sun WP^#, Bi Y^#, Liang H, Cai MY, Chen X, Zhu YH, Li M, Xu F, Yu QQ, He XY, Ye JP, Weng JP*. Inhibition of obesity-induced hepatic ER stress by early insulin therapy in obese diabetic rats. Endocrine, 2011;39(3):235-241. (第一作者，IF=1.416, 3区)

68. Bi Y^#, Zhu DL*, Cheng JL, Zhu Y, Xu N, Cui SW, Li W, Cheng XB, Wang F, Hu Y, Shen SM, Weng JP*. The status of glycemic control: a cross-sectional survey in outpatients with type 2 diabetes mellitus across tertiary, secondary and primary hospitals in Jiangsu Province of China. Clin Ther, 2010, 32(5):973-983. (第一作者，IF=3.25, 3区)

69. Bi Y^#, Cai MY^#, Liang H^#, Sun WP, Li XB, Wang CX, Zhu YH, Chen X, Li M, Weng JP*. Increased CPT-1 expression and decreased SREBP-1c expression is associated with reduced intramuscular triglyceride accumulation after insulin therapy in high fat diet and streptozotocin induced diabetic rats. Metabolism, 2009, 58(6):779-786. (第一作者，IF=2.92, 3区)

70. Liang H^#, Cai MY^#, Bi Y^#, Zhu YH, Yan JH, Weng JP*. A single nucleotide polymorphism (SNP) rs2072907 in the adiponutrin gene (ADPN) was not associated with obesity and type 2 diabetes in Chinese Population. Diabetes Res Clin Pract, 2009, 85(3):e37-e39. (第一作者，IF=2.16, 3区)

71. Bi Y^#, Sun WP, Chen X, Li M, Liang H, Cai MY, Zhu YH, He XY, Xu F, Weng JP*. Effects of early insulin therapy on nuclear factor kB and cytokine gene expressions in the liver and muscle of fat-fed, streptozocin-treated diabetic SD rats. Acta Diabetol, 2008, 45(3):167-178. (第一作者，IF=1.619, 3区)

72. Bi Y^#, Yan JH, Liao ZH, Li YB, Tang KX, Xue YM, Yang HZ, Li L, Cai DH, Wu G, Zhang F, Lin SD, Xiao ZH, Zhu DL*, Weng JP*. Inadequate glycaemic control and antidiabetic therapy among inpatients with type 2 diabetes in Guangdong Province of China. Chinese Med J, 2008, 121(8):677-681. (第一作者，IF=0.858, 3区)

1.糖尿病发病新机制和诊疗新技术（2018-2-66-R2），2018年度江苏省科学技术奖二等奖，第二完成人，江苏省人民政府，2019

2.中国2型糖尿病高血糖病理生理特点及干预新靶点（2018-A-193600P9-1），江苏医学科技奖一等奖，第一完成人，江苏省医学会，2018

3.嗅觉定量诊断在2型糖尿病认知障碍风险预警中的作用及临床应用，江苏省医学新技术引进奖一等奖，第一完成人，江苏省卫健委，2023

4.糖尿病心血管自主神经病变早期筛查技术及其临床应用（2018-3-1），江苏省医学新技术引进奖一等奖，第一完成人，江苏省卫健委，2018

5.1H-MRS定量肝脏脂肪在评估降糖药物疗效中的临床应用（2015-77-1），江苏省医学新技术引进奖一等奖，第一完成人，江苏省卫健委，2015

6.固醇调节原件结合蛋白-1c激活后通过抑制大鼠胰岛素受体底物-1转录介导骨骼肌胰岛素抵抗的作用，2014年度中国糖尿病十大研究最具影响力研究奖，第一完成人，中华医学会糖尿病学分会，2015

7.Association of β-cell function and insulin sensitivity with fasting and 2-h plasma glucose in a large Chinese population，2012年度中国糖尿病十大研究最具影响力研究奖，第一完成人，中华医学会糖尿病学分会，2013

8.糖尿病神经并发症的早期诊断技术研究与临床应用，2022年江苏省瑞华慈善基金会临床研究创新奖三等奖，第一完成人，南京医科大学，2022

9.非酒精性脂肪性肝病新风险指标的建立及临床应用（2022-0-2-1），2022年度南京市医学新技术奖特等奖，第一完成人，南京市卫健委，2022