陈迪俊 教授

25. Liu Y, Zhu T, Zhou Z, Chen W, He C, Zhou X, Wang X, Chen C, Yang B, Wei J, Lan C, Liu M, Su H, Li Q, Hu X, Bi S, Ouyang W, Li X, Mao H, Kishi M, Kaufmann K, Fernie AR^*, Chen D^*, Yan W^*. Integration of the D-Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability. Adv Sci. 2026 Sep 27:e77894. doi: 10.1002/advs.77894. Online ahead of print.

24. Wang X, Liu J, Zhao H, Tang Y, Jiang Y, Zhu T, Tian X, Chen D^*, Lin W^*, Sun B^*. Brassinosteroid signaling regulates shoot apical meristem homeostasis via orchestrating cytokinin and WUSCHEL activity. Sci Adv. 2026 Jun 26;12(26):eaed5120. doi: 10.1126/sciadv.aed5120.

23. Zhang Y, Yang B, Hou X, Ming W, Jin X, Chen G^*, Chen D^*, Zhang W^*. Spatially Resolved Molecular Subtyping Uncovers Tumor Progression and Immune Evasion Mechanisms in High-grade Serous Ovarian Cancer. Cancer Res. 2026 Aug 4;86(15):3873-3894. doi: 10.1158/0008-5472.CAN-25-4749.

22. Chao H, Ruan Z, Li Z, Zhou X, Zhang S, Shen X, Feng C, Chen D^*, Chen M^*. T2T-Hub: a central platform for analyzing plant and animal telomere-to-telomere genomes. Nucleic Acids Res. 2026 Jul 11;54(W1):W131-W136. doi: 10.1093/nar/gkag423.

21. Tong X, Chao H, Zhang C, Li Z, Han Q, Wang L, Wu N, Chen R, Gao J, Zhang S, Xu L, Chen M^*, Zhao H^*, Wang L^*, Chen D^*. A Single-Cell Atlas of Pan-Cancer Liver Metastasis Reveals Dynamic Cellular Programs Driving Metastatic Progression and Immune Modulation. Research. 2026 Mar 24;9:1208. doi: 10.34133/research.1208.

20. Lv T, Han Q, Li Y, Liang C, Ruan Z, Chao H, Chen M, Chen D^*. Cross-species prediction of histone modifications in plants via deep learning. Genome Biol. 2026 Jan 9;27(1):20. doi: 10.1186/s13059-025-03929-4.

19. Zhang Y, Ming W, Yu B, Wang L, Lu K, Xu L, Ni Y, Deng R^*, Chen D^*. Robust integration and annotation of single-cell and spatial omics data using interpretable gene programs. Cell Genom. 2026 Apr 8;6(4):101105. doi: 10.1016/j.xgen.2025.101105.

18. Cao G, Shen Y, Zhao L, Wu J, Chao H, Chen M^*, Chen D^*. CellReasoner: a reasoning-enhanced large language model for cell type annotation. J Genet Genomics. 2026 Apr;53(4):762-765. doi: 10.1016/j.jgg.2025.11.012.

17. Yin X, Anwar A, Yan L, Yu R, Luo Y, Shi L, Li B, Chen J, Liang G, Chen Y, Tang J, Liang J, Kan Y, Zhang Z, Zhou X, Ma J, Ji C, Wang Y, Zhang Q, Li J, Li L, Zhao X, Yin F, Sheng L, Chen D^*, Zhang T^*, Zhang CY^*, Chen X^*. Paternal exercise confers endurance capacity to offspring through sperm microRNAs. Cell Metab. 2025 Nov 4;37(11):2167-2184.e8. doi: 10.1016/j.cmet.2025.09.003.

16. Hawar A, Chen W, Zhu T, Wang X, Liu J, Xiong S, Ito T, Chen D^*, Sun B^*. The histone acetyltransferase GCN5 regulates floral meristem activity and flower development in Arabidopsis. Plant Cell. 2025 Jun 4;37(6):koaf135. doi: 10.1093/plcell/koaf135.

15. Zhou X, Fan HY, Feng XY, Ruan Z, Yuan J, Han Q, He Z, You Y, Chao H, Chen M, Shao ZQ^*, Xue JY^*, Chen D^*. PGCP: A comprehensive database of plant genomes for comparative phylogenomics. Plant Biotechnol J. 2025 Jul;23(7):2928-2930. doi: 10.1111/pbi.70110.

14. Cao G, Chao H, Zheng W, Lan Y, Lu K, Wang Y, Chen M, Zhang H^*, Chen D^*. scPlantLLM: A Foundation Model for Exploring Single-cell Expression Atlases in Plants. Genomics Proteomics Bioinformatics. 2025 Jul 11;23(3):qzaf024. doi: 10.1093/gpbjnl/qzaf024.

13. Zhou X, Ruan Z, Zhang C, Kaufmann K, Chen D^*. Deep learning on chromatin profiles reveals the cis-regulatory sequence code of the rice genome. J Genet Genomics. 2025 Jun;52(6):848-851. doi: 10.1016/j.jgg.2024.12.007.

12. Zhang Y, Yu B, Ming W, Zhou X, Wang J, Chen D^*. SpaTopic: A statistical learning framework for exploring tumor spatial architecture from spatially resolved transcriptomic data. Sci Adv. 2024 Sep 27;10(39):eadp4942. doi: 10.1126/sciadv.adp4942.

11. Zhu T, Xia C, Yu R, Zhou X, Xu X, Wang L, Zong Z, Yang J, Liu Y, Ming L, You Y, Chen D^*, Xie W^*. Comprehensive mapping and modelling of the rice regulome landscape unveils the regulatory architecture underlying complex traits. Nat Commun. 2024 Aug 3;15(1):6562. doi: 10.1038/s41467-024-50787-y.

10. Zhu T, Zhou X, You Y, Wang L, He Z, Chen D^*. cisDynet: An integrated platform for modeling gene-regulatory dynamics and networks. iMeta. 2023 Nov 23;2(4):e152. doi: 10.1002/imt2.152.

9. He Z, Lan Y, Zhou X, Yu B, Zhu T, Yang F, Fu LY, Chao H, Wang J, Feng RX, Zuo S, Lan W, Chen C, Chen M^*, Zhao X^*, Hu K^*, Chen D^*. Single-cell transcriptome analysis dissects lncRNA-associated gene networks in Arabidopsis. Plant Commun. 2024 Feb 12;5(2):100717. doi: 10.1016/j.xplc.2023.100717.

8. He Z, Luo Y, Zhou X, Zhu T, Lan Y, Chen D^*. scPlantDB: a comprehensive database for exploring cell types and markers of plant cell atlases. Nucleic Acids Res. 2024 Jan 5;52(D1):D1629-D1638. doi: 10.1093/nar/gkad706.

7. Zhang S, Fang W, Zhou S, Zhu D, Chen R, Gao X, Li Z, Fu Y, Zhang Y, Yang F, Zhao J, Wu H, Wang P, Shen Y, Shen S, Xu G, Wang L, Yan C^*, Zou X^*, Chen D^*, Lv Y^*. Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis. Nat Commun. 2023 Aug 23;14(1):5123. doi: 10.1038/s41467-023-40727-7.

6. Cao S, He Z, Chen R, Luo Y, Fu LY, Zhou X, He C, Yan W, Zhang CY^*, Chen D^*. scPlant: A versatile framework for single-cell transcriptomic data analysis in plants. Plant Commun. 2023 Sep 11;4(5):100631. doi: 10.1016/j.xplc.2023.100631.

5. Chen ZP, Wang S, Zhao X, Fang W, Wang Z, Ye H, Wang MJ, Ke L, Huang T, Lv P, Jiang X, Zhang Q, Li L, Xie ST, Zhu JN, Hang C, Chen D^*, Liu X^*, Yan C^*. Lipid-accumulated reactive astrocytes promote disease progression in epilepsy. Nat Neurosci. 2023 Apr;26(4):542-554. doi: 10.1038/s41593-023-01288-6.

4. Zhao X, Lan Y, Chen D^*. Exploring long non-coding RNA networks from single cell omics data. Comput Struct Biotechnol J. 2022 Aug 4;20:4381-4389. doi: 10.1016/j.csbj.2022.08.003.

3. Qu J, Yang F, Zhu T, Wang Y, Fang W, Ding Y, Zhao X, Qi X, Xie Q, Chen M, Xu Q, Xie Y^*, Sun Y^*, Chen D^*. A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys. Nat Commun. 2022 Jul 13;13(1):4069. doi: 10.1038/s41467-022-31770-x.

2. Fu LY, Zhu T, Zhou X, Yu R, He Z, Zhang P, Wu Z, Chen M, Kaufmann K^*, Chen D^*. ChIP-Hub provides an integrative platform for exploring plant regulome. Nat Commun. 2022 Jun 14;13(1):3413. doi: 10.1038/s41467-022-30770-1.

1. Zhou X, Zhu T, Fang W, Yu R, He Z, Chen D^*. Systematic annotation of conservation states provides insights into regulatory regions in rice. J Genet Genomics. 2022 Dec;49(12):1127-1137. doi: 10.1016/j.jgg.2022.04.003.

基金

1）基金委面上项目

2）基金委专项项目

3）国家科技重大专项

4）企业资助项目