陈加余 教授

陈加余 博士

Dr. Jiayu Chen

教育背景

2006-2010  山东大学，生命科学学院，生物技术，学士

2010-2015  北京大学，分子医学研究所，生物信息学，博士，导师：李川昀

Education

2006-2010  School of Life Sciences, Shandong University, Biotechnology, Bachelor Degree

2010-2015  Institute of Molecular Medicine, Peking University, Bioinformatics, Doctor Degree, Mentor: Chuan-Yun Li

工作经历

2016-2021  加州大学圣地亚哥分校，细胞与分子医学系， RNA生物学，博士后，导师：付向东

2021-          南京大学，生命科学学院，特任研究员

2021-          南京大学，化学与生物医药创新研究院，特任研究员

Working Experience

2016-2021  Department of Cellular and Molecular Medicine, UCSD, RNA Biology, Postdoctoral Scholar, Mentor: Xiang-Dong Fu

2021-          School of Life Sciences, Nanjing University, Principal Investigator

2021-          Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Principal Investigator

实验室以非经典核酸结构（Non-B DNA Structures）和调控RNA（Regulatory RNA）为主要研究对象，运用前沿学科交叉手段（生物信息学、分子生物学和化学生物学等），首创一系列基因组学技术和算法，解析其分子调控机制和全新生物学功能，以发掘新的核酸药物靶标和生物标志物，并开发新型核酸药物。

热忱欢迎对本实验室研究感兴趣的同学加盟。

The laboratory focuses on studying non-B DNA structures and regulatory RNAs. By leveraging cutting-edge interdisciplinary approaches, we are dedicated to pioneering a range of genomic technologies and algorithms. Our goal is to uncover their molecular regulatory mechanisms and novel biological functions, identify new nucleic acid drug targets and biomarkers, and develop innovative nucleic acid-based therapeutics.

Anyone who has a particular interest in our research is sincerely welcomed to be part of the team.

Selected Publications‍(*first author, #corresponding author, lab members)

NJU (2021 - Now)

(15). Xu, H.*, Ye, J.*, Zhang, K.X.*, Hu, Q., Cui, T., Tong, C., Wang, M., Geng, H., Shui, K.M., Sun, Y., Wang, J., Hou, X., Zhang, K., Xie, R., Yin, Y., Chen, N. and Chen, J.Y.#, Chemoproteomic Profiling Unveils Binding and Functional Diversity of Endogenous Proteins That Interact with Endogenous Triplex DNA, Nat Chem, 2024 (Highlighted by Nat Chem and Nat Rev Chem)

(14). Hu, J.*, Xing, Z.*, Yang, H.*, Zhou, Y.*, Guo, L., Zhang, X., Xu, L., Liu, Q., Ye, J., Zhong, X., Wang, J., Lin, R., Long, E., Jiang, J., Chen, L., Pan, Y., He, L.# and Chen, J.Y.#, Deep Learning-Enhanced R-loop Prediction Provides Mechanistic Implications for Repeat Expansion Diseases, iScience, 2024

(13). Wang, Z., Ge, P., Zhou, X.L., Shui, K.M., Geng, H., Yang, J.#, Chen, J.Y.# and Wang, J.#, nASAP: A Nascent RNA Profiling Data Analysis Platform, JMB, 2023

(12). Hu, J.*, Zhang, Z.*, Xiao, S., Cao, Y., Chen, Y., Weng, J., Jiang, H.#, Li, W.#, Chen, J.Y.# and Liu, C.#, Microhomology-Mediated Circular DNA Formation from Oligonucleosomal Fragments During Spermatogenesis, eLife, 2023

(11). Lin, R.*, Zhong, X.*#, Zhou, Y.*, Geng, H., Hu, Q., Huang, Z., Hu, J., Fu, X.D., Chen, L.# and Chen, J.Y.# R-loopBase: a knowledgebase for genome-wide R-loop formation and regulation, Nucleic Acids Res, 2022

Before 2021

(10). Chen, J.Y., Lim, D.H. and Fu, X.D. Mechanistic Dissection of RNA Binding Proteins in Regulated Gene Expression at Chromatin Levels, Cold Spring Harb Symp Quant Biol, 2019

(9). Xiao, R.*, Chen, J.Y.* et al., Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription, Cell, 2019

(8). Chen, J.Y. et al., R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1, Nat Protoc, 2019

(7). An, N.A.*, Ding, W. *, Yang, X.Z.*, …, Chen, J.Y.#and Li, C.Y.#, Evolutionarily significant A-to-I RNA editing events originated through G-to-A mutations in primates, Genome Biol, 2019

(6). Chen, L.*, Chen, J.Y.* et al., The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations, Mol Cell, 2018 (Highlighted by Cancer Discov, recommended by Faculty of 1000, and selected as Cover Story)

(5). Chen, L.*, Chen, J.Y.*, Zhang, X., Gu, Y., Xiao, R., Shao, C., …, Fu, X.D. et al., R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters, Mol Cell, 2017 (Highlighted by Nat Rev Genet and Nat Methods)

(4). Chen, J.Y.* et al., Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates, PLoS Genet, 2015 (Recommended by Faculty of 1000)

(3). Yang, X.Z.*, Chen, J.Y.* et al., Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates, Mol Biol Evol, 2015

(2). Chen, J.Y.* et al., RNA Editome in Rhesus Macaque Shaped by Purifying Selection, PLoS Genet, 2014

(1). Xie, C.*, Zhang, Y.E.*, Chen, J.Y.* et al., Hominoid-specific De Novo Protein-coding Genes Originating from Long Non-coding RNAs, PLoS Genet, 2012 (Recommended by Faculty of 1000)

2025  江苏省杰出青年

2024  教育部青年长江学者

2021  江苏省特聘教授

2019  美国国立卫生院职业发展独立成就奖（NIH K99/R00）

2015  北京大学优秀博士生毕业论文

2014  吴瑞奖学金 (被誉为华人生物学在读博士最高奖)

2025  Distinguished Young Scholar of Jiangsu Province

2024  Chang Jiang Scholars Program - Young Scholar

2021  Specially-Appointed Professor of Jiangsu Province

2019  NIH Pathway to Independence Award (NIH K99/R00)

2015  Excellent Doctoral Dissertation, Peking University

2014  Ray Wu Prize