华子春 教授

长期从事智能活体微生物药物、肿瘤免疫治疗新方法；多肽与蛋白质工程、蛋白质结构与功能；细胞凋亡信号的新功能及其相关新药研发

1. Baolian Huang, Te Yin, Shuilian Fu, Lina Liu, Chen Yang, Lulu Zhou, Xing Liu, Hongqin Zhuang, Zhiting Cao*,

    Zichun Hua*

    Inflammation-oriented montmorillonite adjuvant enhanced oral delivery of anti-TNF-α nanobody against

    inflammatory bowel disease

    Proc Natl Acad Sci USA 2024, 121(37):e2320482121

2. Leyang Wu, Liyuan Qiao, Shuhui Zhang, Jiahui Qiu, Zengzheng Du, Ying Sun, Xiaoyao Chang, Lin Li, Chenyang 

    Li, Xinyue Qiao, Xingpeng Yin, Zichun Hua*

     Dual-Engineered Macrophage-Microbe Encapsulation for Metastasis Immunotherapy

    Advanced Materials 2024, 2406140(1-17)

3. Leyang Wu, Lin Li, Liyuan Qiao, Chenyang Li, Shuhui Zhang, Xingpeng Yin, Zengzheng Du, Ying Sun, Jiahui

    Qiu, Xiaoyao Chang, Bohao Wang, Zichun Hua*

      Programmable Bacteria with Dynamic Virulence Modulation System for Precision Antitumor Immunity

    Advanced Science 2024, 2404069(1-18) 

4. Leyang Wu, Zengzheng Du, Lin Li, Liyuan Qiao, Shuhui Zhang, Xingpeng Yin, Xiaoyao Chang, Chenyang Li, 

    Zichun Hua*

     Camouflaging attenuated Salmonella by cryo-shockedmacrophages for tumor-targeted therapy

   Signal Transduction and Targeted Therapy 2024, 9:14

5. Lina Liu, Xing Liu, Wenjie Xin, Lulu Zhou, Baolian Huang, Chao Han, Zhiting Cao*, Zichun Hua*

    A bacteria-based system expressing anti-TNF-α nanobody for enhanced cancer immunotherapy

    Signal Transduction and Targeted Therapy 2023, 8:134

6. Shuilian Fu, Zhiting Cao, Baolian Huang, Te Yin, Chujun Huang, Zhiqian Bi, Yingying Yao, Xiaoyao Chang, Hongqin Zhuang*, 

    ZiChun Hua*

    Tannic acid assisted anti-TNF-α nanobody assembly modulating the epithelial barrier dysregulation of allergic rhinitis

           Nano Research 2023, 16:9781–9791

7. Lina Liu, Wenjie Xin, Qiang Li, Baolian Huang, Te Yin, Siqi Hua, Chen Yang, Chen Chen, Chao Han, Zichun Hua*

    Neutrophil-Mediated Tumor-Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis

    Therapy

    Advacnced Sience 2023, 10:2301835.

8. Yanguan Guo, Jiaxin Tian, Yongjian Guo, Cong Wang, Congcong Chen, Songwang Cai, Wenliang Yu, Binghe Sun, Jin Yan,

    Zhonghua Li, Jun Fan, Qi Qi, Dongmei Zhang, Weilin Jin, Zichun Hua*, Guo Chen*

    Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating b-catenin

    Cell Reports 2023, 42:113511,

9. Leyang Wu†, Lin Li†, Shufeng Li†, Lina Liu, Wenjie Xin, Chenyang Li, Xingpeng Yin, Xuebo Xu, Feifei Bao, Zichun Hua*

    Macrophage-mediated tumor-targeted delivery of engineered Salmonella typhimurium VNP20009 in anti–PD1 therapy against

    melanoma

    Acta Pharmaceutica Sinica B 2022, 11(10):3165-3177. 

10.Leyang Wu, Feifei Bao, Lin Li, Xingpeng Yin, Zichun Hua*

    Bacterially mediated drug delivery and therapeutics: Strategies and advancements

    Advanced Drug Delivery Reviews August 2022, 187:114363   

11.Li-Jun Song, Xu-Ren Yin, Sheng-Wen Guan, Hong Gao, Pan-Pan Dong, Cong-Jin Mei, Ying-Ying Yang, Ying Zhang, Chuan-Xin Yu,

     Zi-Chun Hua*

     RIP3 deficiency attenuated hepatic stellate cell activation and liver fibrosis in schistosomiasis through JNK-cJUN/Egr1

     downregulation

     Signal Transduction and Targeted Therapy 2022, 7:193

12.Leyang Wu, Feng Chen, Xiaoyao Chang, Lin Li, Xingpeng Yin, Can Li, Fangxu Wang, Chenyang Li, Qin Xu, Hongqin Zhuang,*

     Ning Gu,* Zi-Chun Hua*

    Combined Cellular Thermometry Reveals That Salmonella typhimurium Warms Macrophages by Inducing a Pyroptosis-like

    Phenotype

    Journal of the American Chemical Society 2022, 144(42):19396-19409

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先后获国家技术发明二等奖（2013年）、国家自然科学二等奖（2000年）各1项；获江苏省一等奖4项（2004、2011、2014、2017年），教育部一等奖（1998、2018、2023年）3项，全国颠覆性技术创新大赛总决赛优胜奖，中国专利优秀奖，中国国际工业博览会银奖，中国产学研合作创新成果一等奖，发明创业成果奖一等奖（2项），中国侨界贡献奖-创新成果奖，首届江苏创新创业大赛一等奖等奖励。