姜晓宏 教授

姜晓宏，南京大学生命科学学院教授，博士生导师。国家青年拔尖人才入选者。聚焦代谢性疾病方向研究，以第一或通讯作者（含共通讯）在Circulation Research、PNAS、Nat Commun、Diabetologia、J Extracell Vesicles等学科一流期刊发表SCI论文30余篇曾获教育部自然科学一等奖，江苏省医学科学一等奖，任江苏省生理科学学会会青委会主任委员。

从事哺乳动物代谢性疾病的研究，专注于糖脂代谢时空调控，尤其是肥胖导致的Ⅱ型糖尿病和心血管疾病。主要是从转录和转录后加工水平对线粒体的功能进行研究，从线粒体的生理功能到病理转变的全新角度，解释多种代谢性疾病潜在的分子生物学机制与联系。对各种代谢性疾病，尤其是肥胖引起的代谢综合症，从回复线粒体功能，恢复机体能量平衡的角度寻找新的更有效治疗途径和药物靶点。

专注于糖脂代谢时空调控，以及肥胖和糖尿病发病机制研究，取得一系列研究成果，在Nature communications, PNAS, Diabetologia等权威杂志发表高水平研究论文30余篇，获得高等学校科学研究优秀成果奖自然科学一等奖一项，江苏省医学科技奖一等奖一项。

      主要研究方向：

1）肥胖与2型糖尿病的分子机制及靶向治疗

2）心血管疾病的分子机制与运动干预治疗

3）小核酸药物体内靶向递送系统

江苏省生理科学会青年委员会主任委员

代表性论文：

1）Wei Z^#, Chong H^#, Jiang Q^#, Tang Y, Xu J, Wang H, Shi Y, Cui L, Li J, Zhang Y, Xue Y, Li J, Liu G, Chen X, Wang D*, Zhang CY*, Jiang X*. (2021) Smooth muscle overexpression of PGC1α attenuates atherosclerosis in rabbits. Circ Res. 2021 Aug 6; 129 (4): e72-e86.

2）Li J#, Zhang Y#, Ye Y#, Li D#, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A*, Jiang X*, Zhang CY*. (2021) Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles. 2021 Jan; 10(3):e12055.

3)  Li D#, Song H#, Shuo L, Wang L, Xie P, Li W, Liu J, Tong Y, Zhang CY, Jiang X*, Li J*, Zhang Y*. (2020) Gonadal white adipose tissue-derived exosomal MiR-222 promotes obesity-associated insulin resistance. Aging-US (Albany NY). 2020 Nov 10; 12(22):22719-22743.

4)  Ye Y#, Zhang X#, Xie F, Xu B, Xie P, Yang T, Shi Q, Zhang CY, Zhang Y, Chen J*, Jiang X*, Li J*. (2020) An engineered exosome for delivering sg RNA:Cas9 ribonucleoprotein complex and genome editing in recipient cells. Biomaterials Science. 2020 May 19; 8(10):2966-2976.

5）Chong H#, Wei Z#, Namuhan#, Sun G, Zheng S, Zhu X, Xue Y, Zhou Q, Guo S, Xu J, Wang H, Cui L, Zhang CY*, Jiang X*, Wang D*. (2020) The PGC-1α/NRF1/miR-378a axis protects vascular smooth muscle cells from FFA-induced proliferation, migration and inflammation in atherosclerosis. Atherosclerosis. 2020 Mar; 297:136-145.

6）Zheng S*, Guo S*, Sun G*, Shi Y, Wei Z, Tang Y, He F, Shi C, Dai P, Chong H, Samuelson I, Zen K, Zhang CY, Zhang Y#, Li J#, Jiang X#. (2019) Gain of metabolic benefit with ablation of miR-149-3p from subcutaneous adipose tissue in diet-induced obese mice. Mol Ther Nucleic Acids. 2019 Dec 6; 18:194-203.

7）Li J*, Jiang X*, Wang K. (2019) Exosomal miRNA: an alternative mediator of cell-to-cell communication. ExRNA. 2019 Jul 11; 1:31.

8)  Jiang X*, Hou D*, Wei Z, Zheng S, Zhang Y#, Li J#. (2019) Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance. ExRNA. 2019 Apr 3; 1:17. doi:10.1186/s41544-019-0014-0.

9）Hou D*, He F*, Ma L*, Cao M*, Zhou Z, Wei Z, Xue Y, Sang X, Chong H, Tian C, Zheng S, Li J, Zen K, Chen X, Hong Z#, Zhang CY#, Jiang X#. (2018) The potential atheroprotective role of plant MIR156a as a repressor of monocyte recruitment on inflamed human endothelial cells. J Nutr Biochem. 2018 Jul; 57: 197-205.

10) Liu Y, Chen X, Cheng R, Yang F, Yu M, Wang C, Cui S, Hong Y, Liang H, Liu M, Zhao C, Ding M, Sun W, Liu Z, Sun F, Zhang C, Zhou Z#, Jiang, X#, Chen X#. (2018) The Jun/miR-22/HuR regulatory axis contributes to tumorigenesis in colorectal cancer. Mol Cancer. 2018 Jan 19; 17(1):11.

11) Xu Z*, Wang Q*, Pan J*, Sheng X, Hou D, Chong H, Wei Z, Zheng S, Xue Y, Zhou Q, Cao H, Zhang CY#, Wang D#, Jiang X#. (2017) Characterization of serum miRNAs as molecular biomarkers for acute Stanford type A aortic dissection diagnosis. Sci Rep. 2017 Oct 20; 7 (1):13659.

12) Ding H*, Zheng S*, Garcia-Ruiz D, Hou D, Wei Z, Liao Z, Li L, Zhang Y, Han X, Zen K, Zhang CY#, Li J#, Jiang X#. (2016) Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16. Nature Commun. 2016 May 31; 7:11533.

13) Xue Y*, Wei Z*, Ding H*, Wang Q, Zhou Z, Zheng S, Zhang Y, Hou D, Liu Y, Zen K, Zhang CY, Li J#, Wang D#, Jiang X#. (2015) MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis. Atherosclerosis. 2015 Aug; 241(2):671-81.

14) Cao M*, Nie W*, Li J*, Zhang Y, Yan X, Guan X, Chen X, Zen K, Zhang CY#, Jiang X#, Hou D#. (2014). MicroRNA-495 induces breast cancer cell migration by targeting JAM-A. Protein Cell. 2014 Nov; 5 (11): 862-72.

15) Ding H*, Zhang Y*, Xu C*, Hou D, Li J, Zhang Y, Peng W, Zen K, Zhang CY#, Jiang X#. (2014) Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance through inhibition of PTP1B. Diabetologia. 2014 Oct; 57(10):2145-54.

16) Jiang X, Chen YC, Gong H, Trang P, Lu S, Liu F. (2012) Ribonuclease P-mediated inhibition of human cytomegalovirus gene expressionand replication induced by engineered external guide sequences. RNA Biol. 2012 Sep 9 (9):1186-95.

17) Jiang X, Gong H, Chen YC, Vu GP, Trang P, Zhang CY, Lu S#, Liu F#. (2012) Effective inhibition of cytomegalovirus infection by external guide sequences in mice. Proc Natl Acad Sci USA. 2012 Aug 7; 109 (32):13070-5.

18) Jiang X, Bai Y, Rider P, Kim K, Zhang CY, Lu S#, Liu F#. (2011) Engineered external guide sequences effectively block viral gene expression and replication in cultured cells. J Biol Chem. 2011 Jan 7; 286(1): 322-30.

19) Jiang X*, Zhang Y*, Hou D*, Zhu L, Xu W, Ding L, Qi X, Sun G, Liu C, Zhang J, Zen K#, Xiang Y#, Zhang CY#. (2010) 17beta-estradiol inhibits oleic acid-induced rat VSMC proliferation and migration by restoring PGC-1alpha expression. Mol Cell Endocrinol. 2010 Feb 5; 315(1-2):74-80.

撰写书籍专章1章，发表在系列丛书Methods in Molecular Biology (Clifton, N.J.) 2014年版的第4章节中：

作者姓名：Jiang X, Sunkara N, Lu S, Liu F.

出版时间：2014年

专著名称：Methods in Molecular Biology (Clifton, N.J.).- Therapeutic Applications of Ribozymes and Riboswitches中第四章：Directing RNase P-mediated cleavage of target mRNAs by engineeredexternal guide sequences in cultured cells.

出版机构所在地：United Kingdom

出版机构：Springer

起止页码：Volume: 1103; Pages:45-56

主编姓名：Daniel Lafontaine and Audery Dube

专著总页码：278页

2011年，高等学校科学研究优秀成果奖自然科学一等奖