刘常宏 教授

1. 生防菌-病原菌-植物的互作机理及代谢调控网络
    Interaction mechanism and metabolitic regulation network of biocontrol agent - pathogen - plants
2. 海底深部真菌多样性及其在元素地球化学循环过程中的作用 
   Fungal diversity and roles in element biogeochemical cycle in deep environments below sea floor

江苏省微生物学会理事，教学委员会主任；Hans Journal of Agricultural Sciences (HJAS)编委；Journal of Applied Life Sciences International编委；The Journal of Microbiology, Biotechnology and Food Sciences编委

在研的科研项目

1. 国家自然科学基金重大研究计划——“水圈微生物驱动地球元素循环的机制”（简称“水圈微生物计划”)”培育项目，91951121，洋底深部真菌反硝化产N₂新途径及原位作用模拟，2020/01-2022/12，主持。

2. 国家自然科学基金(41973073)：洋底深部极端环境硫酸盐还原真菌的发现及其异化硫酸盐还原机理和原位作用模拟研究，2020/01-2023/12，主持。

3. 国家自然科学基金(41773083)：洋底深部真菌利用褐煤产甲烷的生化过程及代谢机理。2018/01-2021/12，主持。

5. 国家重点研发计划（2017YFD0800700）：“农业面源和重金属污染农田综合防治与修复技术研究”专项，“农田有毒有害化学/生物污染防控技术与产品研发”项目；课题名称：有毒有害生物源头防控、失活及绿色防控技术与产品研发（2017YFD0800705）。2017/7-2020/12，参与。

近5年发表的主要论文

2020

1.M. Zain Ul Arifeen# , Xinyi Yang# , Fangfang Li, Yarong Xue, Pixian Gong, Changhong Liu. Growth behaviors of deep subseafloor Schizophyllum commune in response to various environmental conditions. Acta Microbiologica Sinica 2020, 60(9): 1882-1892.

2.Muhammad Zain ul Arifeen, Yu-Nan Ma, Ya-Rong Xue and Chang-Hong Liu *. Deep-sea fungi could be the new arsenal for bioactive molecules. Marine Drugs 2020, 18(1): 9.

3.Jia S, Bian K, Shi P*, Ye L, Liu C-H. Metagenomic profiling of antibiotic resistance genes and their associations with bacterial community during multiple disinfection regimes in a full-scale drinking water treatment plant. Water Research 2020, 176: 115721

4.Liqun Xing, Meng Tao, Qin Zhang, Ming Kong, Jie Sun, Shuyu Jia, Chang-Hong Liu. Occurrence, spatial distribution and risk assessment of organophosphate esters in surface water from the lower Yangtze River Basin. Science of the Total Environment 2020, 734: 139380.

5.Jun Li, Ying Liang, Yu Miao, Depeng Wang, Shuyu Jia, Chang-Hong Liu. Metagenomic insights into aniline effects on microbial community and biological sulfate reduction pathways during anaerobic treatment of high-sulfate wastewater. Science of The Total Environment 2020, 742: 140537.

2019

6.Kang XX, Wang LH, Guo Y, Muhammad Zain ul Arifeen, Cai XC, Xue YR*, Bu YQ, Wang G, Liu CH*. A comparative transcriptomic and proteomic analysis of hexaploid wheat’s responses to colonization by Bacillus velezensis and Gaeumannomyces graminis, both separately and combined. Molecular Plant-Microbe Interactions 2019, 32(110): 1336-1347.  

7.Kang XX, Guo Y, Leng S, Xiao L, Wang LH, Xue YR*, Liu CH*. Comparative transcriptome profiling of Gaeumannomyces graminis var. tritici in wheat roots in the absence and presence of biocontrol Bacillus velezensis CC09. Frontiers in Microbiology 2019, 10: 1474.

8.Wang YT*, Shi TQ, Zhu HL*, Liu CH*. Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry 2019, 27(3): 502-515.

9.Arifeen M.Z.U., Xue YR., Liu CH. Deep-Sea Fungi: Diversity, Enzymes, and Bioactive Metabolites. In: Tiquia-Arashiro S., Grube M. (eds) Fungi in Extreme Environments: Ecological Role and Biotechnological Significance. Springer, Cham. 2019, pp 331-347.

10.Arifeen MZU, Xue YR, Liu CH. Deep-Sea Fungi: Diversity, Enzymes, and Bioactive Metabolites. In: Tiquia-Arashiro S., Grube M. (eds) Fungi in Extreme Environments: Ecological Role and Biotechnological Significance. Springer, Cham. 2019, pp 331-347.

2018年

11.Kang XX, Zhang WL, Cai XC, Zhu T, Xue YR*, and Liu CH*. Bacillus velezensis CC09: A potential ‘vaccine’ for controlling wheat diseases. Molecular Plant-Microbe Interactions 2018, 31(6): 623-632.

12.Huang X, Duan N, Xu H, Xie TN, Xue YR, and Liu CH*. CTAB-PEG DNA extraction from fungi with high contents of polysaccharides. Molecular Biology 2018, 52(4): 621-628.

13.Li J, Du M, Lv G, Zhou L, Li X, Bertoluzzi L, Liu CH, Zhu S, Zhu J*. Interfacial solar steam generation enables fast-responsive, energy-efficient and low-cost off-grid sterilization. Advanced Materials 2018, 30(49): 1805159.

14.Muhammad Zain Ul Arifeen, Chang-Hong Liu. Novel Enzymes Isolated from Marine-derived Fungi and its Potential Applications. Journal of Biotechnology and Bioengineering 2018, 2(4): 1-12.

2017

15.Liu CH*, Huang X, Xie TN, Duan N, Xue YR, Zhao TX, Lever MA, Hinrichs K-U, Inagaki F. Exploration of cultivable fungal communities in deep coal-bearing sediments from ~1.3 to 2.5 km below the ocean floor. Environmental Microbiology 2017, 19(2): 803-818.

16.Cai XC, Liu CH*, Wang BT, Xue YR*. Genomic and metabolic traits endow Bacillus velezensis CC09 with a potential biocontrol agent in control of wheat powdery mildew disease. Microbiological Research 2017, 196: 89-94.

17.Cai XC, Xi H, Liang L, Liu JD, Liu CH*, Xue YR, Yu XY. Rifampicin-resistance mutations in the rpoB gene in Bacillus velezensis CC09 have pleiotropic effects. Frontiers in Microbiology 2017, 8: 178. 

18.Wang YT, Cai XC, Shi TQ, Zhang YL, Wang ZC*, Liu CH*, Zhu HL*. Synthesis, molecular docking and biological evaluation of 1-phenylsulphonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as novel potential tubulin assembling inhibitors. Chemical Biology & Drug Design 2017, 90: 112-118.  

2016

19.Chen RQ, Li FF, Liu JD, Zheng HY, Shen F, Xue YR*, Liu CH*. The combined effects of Dolichospermum flos-aquae, light, and temperature on microcystin production by Microcystis aeruginosa. Chinese Journal of Oceanology and Limnology 2016, 34: 1173-1182.

20.Wang YT, Liu CH, Zhu HL. Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015). Expert Opinion on Therapeutic Patents 2016, 26(7): 767-76.

21.Zeng LW, Zhou CX, Liu JD, Liu CH, Mo JX, Hou AF, Yao W, Wang ZZ, Gan LS. Design, synthesis, and antimicrobial activities of new tanshinone IIA esters. Natural Product Research 2016, 1: 1-7.

22.Cai XC, Kang XX, Xi H, Liu CH*, Xue YR*. Complete genome sequence of the endophytic biocontrol strain Bacillus velezensis CC09. Genome Announcement 2016, 4(5): e01048-16.

23.Fumio Inagaki, Kai-Uwe Hinrichs, Yusuke Kubo, and the IODP Expedition 337 Scientists. IODP Expedition 337: Deep Coalbed Biosphere off Shimokita - Microbial processes and hydrocarbon system associated with deeply buried coalbed in the ocean. Scientific Drilling. 2016, 21: 17-28.

2015

24.Inagaki F, Hinrichs K-U, Kubo Y, Bowles MW, Heuer VB, Hong W-L, Hoshino T, Ijiri A, Imachi H, Ito M, Kaneko M, Lever MA, Lin Y-S, Methé BA, Morita S, Morono Y, Tanikawa W, Bihan M, Bowden SA, Elvert M, Glombitza C, Gross D, Harrington GJ, Hori T, Li K, Limmer D, Liu CH, Murayama M, Ohkouchi N, Ono S, Park Y-S, Phillips SC, Prieto-Mollar X, Purkey M, Riedinger N, Sanada Y, Sauvage J, Snyder G, Susilawat R, Takano Y, Tasumi E, Terada T, Tomaru H, Trembath-Reichert E, Wang DT, Yamada Y. Exploring deep microbial life in coal-bearing sediment down to ~2.5 km below the ocean floor. Science 2015, 349(6246): 420-424.

25.Wang YT, Qin YJ, Yang N, Zhang YL, Liu CH*, Zhu HL*. Synthesis, biological evaluation, and molecular docking studies of novel 1-benzene acyl-2-(1-methylindol- 3-yl)-benzimidazole derivatives as potential tubulin polymerization inhibitors. European Journal of Medicinal Chemistry 2015, 99: 125-137.

26.Wang YT, Xue YR, Liu CH*. A brief review of bioactive metabolites derived from deep-sea fungi. Marine Drugs 2015, 13: 4594-4616.

27.Zheng YT, Jia RN, Qian YQ, Ye Y, Liu CH*. Correlation between electric potential and peristaltic behavior in Physarum polycephalum. BioSystems 2015, 132: 13-19.

1.2017年度环境保护科学技术奖二等奖：微生物农药生态环境安全性评价与安全使用技术。 

2.2007年教育部高等学校科学技术奖（自然科学奖）一等奖：植物内生真菌代谢物研究”。

3.2005年教育部提名国家科学技术奖（自然科学奖）一等奖：民间常用草药成分的分析与功能研究。