个人简介研究方向1，多聚磷酸盐的化学生物学： 聚焦多聚磷酸盐（PolyP）的化学生物学，揭示其在生命体中的合成、代谢机制；驱动液-液相分离调控细胞功能的分子机制；建立修饰组学方法，解析多聚磷酸盐介导的蛋白质多聚磷酸化新修饰类型及功能；并开发高聚合度PolyP的工程菌生产及在化妆品、骨修复、肠道健康等领域的转化应用。 2，生物体内微量金属元素和无机多聚物的代谢机制及调控功能： 微量金属元素和无机多聚物在生命过程中有着一系列其他物质所不能替代的特殊作用。这些物质在体内的代谢水平紊乱，会导致多种疾病,包括癌症、神经退行性疾病、中风、脑出血、创伤性脑损伤等。为了研究其在生物体内的代谢机制及调控功能，我们将运用化学生物学，生物无机化学，微生物学，合成生物学和蛋白质组学等多学科交叉的研究方法。 3，基于光电驱动的新型半人工光合作用： 半人工光合作用系统是通过将具有光电催化功能的材料与具有生物活性的酶/微生物细胞复合构建的杂化系统，是合成生物学，化学生物学和材料科学等学科国际学者共同关注的热点。设计开发新型的半人工光合系统并应用到医药和生物技术研究中将具有重要的科研价值和巨大的社会效益。 学术兼职工作经历科研成果1. Zhu, L.; Wen, Z.; Yu, M.; Zhang, J.; Qin, Y.; Gao, S.; Mao, Y.; Deng, Y.; Tian, T.; Liu, S.; Jiang, W.; Ma, J.; Wang, X.; Guo, Z.; Wei, W.; Zhao, J.; Wang, X., Chirality-Driven Immune Checkpoint Modulation by Chiral Iridium(III) Nanoparticles. J Am Chem Soc 2026, 148 (17), 17794-17810. 2. Ji, L.; Zhu, T.; Jiang, T.; Wang, L.; Qiu, Z.; Gao, S.; Wang, Y.; Wang, J.; Zhang, J.; Huang, H.; Mao, Y.; Lin, C.; Zhao, J.; Wang, X.; Wei, W., A live biohybrid bacterial therapy based on engineered Serratia marcescens. Nat Commun 2026. 3. Chen, Y.; Wang, X.; Wei, W.; Zhang, L.; Zhao, J.; Qian, Y., Dual-Emission Fluorescent Probe for Simultaneous Visualization of Monoamine Oxidase A and Lysyl Oxidase in Alzheimer's Disease Cell Models. Chem Biomed Imaging 2026, 4 (2), 187-198. 4. Wang, Z. C.; Zhao, J.; He, S. S.; Li, R. P.; Wang, X. X.; Yan, C.; Zhao, J.; Wei, W., Inorganic Polyphosphate Relieves Ulcerative Colitis by Modulating the Gut Microbiota and Metabolites. Acs Applied Bio Materials 2025. 5. Li, X. Z.; Zhao, X.; Wang, X. Y.; Xiong, A. X.; Wang, Z. C.; Shi, Z. L.; Zhang, J. Y.; Wang, H. L.; Wei, W.; He, C.; Ma, J. J.; Guo, Z. J.; Duan, C. Y.; Zhao, J.; Wang, X. X., Programmable Modular Assembly of Homochiral Ir(III)-Metallohelices to Reverse Metallodrug Resistance by Inhibiting CDK1. Angewandte Chemie-International Edition 2025, 64 (7). 6. Chen, Z. P.; Wu, Y. L.; Qin, L. F.; Wang, C.; Li, Z. X.; Luo, X. Z.; Wei, W.; Zhao, J., A systematic study of regulating inorganic polyphosphates production in. Synthetic and Systems Biotechnology 2025, 10 (3), 816-826. 7. Chen, J.; Lei, D.; Liu, X.; Chen, Z.; Li, J.; Huang, L.; Liu, H.; Yang, X.; Wei, W.; Xie, S., Biosynthetic polyphosphate enhances osteogenesis of human periodontal ligament stem cells and promotes periodontal bone regeneration in a murine periodontal bone defect model. Front Bioeng Biotechnol 2025, 13, 1672295. 8. Zhu, L.; Wang, X. Y.; Tian, T.; Chen, Y. Y.; Du, W. J.; Wei, W.; Zhao, J.; Guo, Z. J.; Wang, X. X., A Λ-Ir(III)-phenylquinazolinone complex enhances ferroptosis by selectively inhibiting metallothionein-1. Chemical Science 2024, 15 (27), 10499-10507. 9. Zhao, X. Y.; Wang, X. Y.; Zhang, W.; Tian, T.; Zhang, J. Y.; Wang, J.; Wei, W.; Guo, Z. J.; Zhao, J.; Wang, X. X., A Ferroptosis-Inducing Arsenene-Iridium Nanoplatform for Synergistic Immunotherapy in Pancreatic Cancer. Angewandte Chemie-International Edition 2024, 63 (15). 10. Zhao, J.; Wang, C.; Liu, J.; Zhang, N.; Zhao, Y.; Zhao, J.; Wang, X.; Wei, W., A biocompatible surface display approach in Shewanella promotes current output efficiency. Biosens Bioelectron 2024, 259, 116422. 11. Zhang, X.; Zhou, Y.; Yang, H.; Wei, W.; Zhao, J., Ratiometric absorbance and fluorescence dual model immunoassay for detecting ochratoxin a based on porphyrin metalation. Food Chem 2024, 464 (Pt 1), 141608. 12. Zhang, J. Y.; Qin, Y.; Chen, Y. M.; Zhao, X. Y.; Wang, J.; Wang, Z. Z.; Li, J. Y.; Liu, S. J.; Guo, Z. J.; Wei, W.; Zhao, J.; Wang, X. X., Ultrathin 2D As2Se3 Nanosheets for Photothermal-Triggered Cancer Immunotherapy. Acs Nano 2024, 18 (5), 4398-4413. 13. Xie, Z. Y.; Cao, B.; Zhao, J.; Liu, M. Y.; Lao, Y. H.; Luo, H. J.; Zhong, Z.; Xiong, X. L.; Wei, W.; Zou, T. T., Ion Pairing Enables Targeted Prodrug Activation via Red Light Photocatalysis: A Proof-of-Concept Study with Anticancer Gold Complexes. Journal of the American Chemical Society 2024, 146 (12), 8547-8556. 14. Wang, J.; Zhao, X.; Tao, Y.; Wang, X.; Yan, L.; Yu, K.; Hsu, Y.; Chen, Y.; Zhao, J.; Huang, Y.; Wei, W., Biocompatible aggregation-induced emission active polyphosphate-manganese nanosheets with glutamine synthetase-like activity in excitotoxic nerve cells. Nature Communications 2024, 15 (1), 3534. 15. Chen, Y. Y.; Hao, T. T.; Wang, J.; Chen, Y. M.; Wang, X. X.; Wei, W.; Zhao, J.; Qian, Y., A Near-Infrared Fluorogenic Probe for Rapid, Specific, and Ultrasensitive Detection of Sphingosine in Living Cells and In Vivo. Advanced Science 2024, 11 (2). 16. Zhu, L.; Du, W. J.; Li, Y. R.; Li, D.; Wei, W.; Zhao, J.; Wang, X. X., Chiral SPINOL-Based Pt(II) Metallacycles For Immunogenic Cell Death. Inorganic Chemistry 2023, 62 (37), 14922-14930. 17. Zhao, X. Y.; Zhang, J. Y.; Zhang, W.; Guo, Z. J.; Wei, W.; Wang, X. X.; Zhao, J., A chiral fluorescent Ir(iii) complex that targets the GPX4 and ErbB pathways to induce cellular ferroptosis. Chemical Science 2023, 14 (5), 1114-1122. 18. Zhang, X. P.; Chen, X. W.; Feng, Y. J.; Yang, H. L.; Wei, W.; Zhao, J., Development of a bioluminescence immunoassay for detecting ochratoxin A based on luciferin oxidation catalyzed by luciferase. Journal of Food Composition and Analysis 2023, 124. 19. Zhang, J. Y.; Qin, Y.; Wang, Z. C.; Zhang, W.; Liu, S. J.; Wei, W.; Wang, X. X.; Zhao, J., Ferroptosis-inducing inorganic arsenic(II) sulfide nanocrystals enhance immune activation. Nano Research 2023, 16 (7), 9760-9767. 20. Sun, P. Q.; Li, K. L.; Liu, X.; Wang, J.; Qiu, X. S.; Wei, W.; Zhao, J., Peptide-mediated Aqueous Synthesis of NIR-II Emitting Ag2S Quantum Dots for Rapid Photocatalytic Bacteria Disinfection. Angewandte Chemie-International Edition 2023, 62 (14). 21. Li, X. Z.; Wang, Z. C.; Hao, X. R.; Zhang, J. Y.; Zhao, X.; Yao, Y. G.; Wei, W.; Cai, R.; He, C.; Duan, C. Y.; Guo, Z. J.; Zhao, J.; Wang, X. X., Optically Pure Double-Stranded Dinuclear Ir(III) Metallohelices Enabled Chirality-Induced Photodynamic Responses. Journal of the American Chemical Society 2023, 145 (27), 14766-14775. 22. Chen, Y.; Jiang, H.; Hao, T.; Zhang, N.; Li, M.; Wang, X.; Wang, X.; Wei, W.; Zhao, J., Fluorogenic Reactions in Chemical Biology: Seeing Chemistry in Cells. Chem Biomed Imaging 2023, 1 (7), 590-619. 23. Zhang, X. P.; Wang, J. J.; Juan, Y. W.; Yang, H. L.; Wei, W.; Zhao, J., A novel fluorescence method for detection of phosphate anions based on porphyrin metalation. Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy 2022, 274. 24. Wang, X. X.; Zhang, J. Y.; Hu, Y.; Zhao, X. Y.; Wang, Z. C.; Zhang, W.; Liang, J. C.; Yu, W. H.; Tian, T.; Zhou, H.; Li, J.; Liu, S. J.; Zhao, J.; Jin, Z.; Wei, W.; Guo, Z. J., Multi-Omics Analysis Reveals the Unexpected Immune Regulatory Effects of Arsenene Nanosheets in Tumor Microenvironment. Acs Applied Materials & Interfaces 2022. 25. Wang, X. X.; Han, Z. C.; Wei, W.; Hu, H. S.; Li, P. F.; Sun, P. Q.; Liu, X. Z.; Lv, Z. J.; Wang, F.; Cao, Y.; Guo, Z. J.; Li, J.; Zhao, J., An unexpected all-metal aromatic tetranuclear silver cluster in human copper chaperone Atox1. Chemical Science 2022, 13 (24), 7269-7275. 26. Wang, J.; Tao, Y. C.; Juan, Y. W.; Zhou, H.; Zhao, X. Y.; Cheng, X. M.; Wang, X. X.; Quan, X. B.; Li, J. N.; Huang, K.; Wei, W.; Zhao, J., Hierarchical Assembly of Flexible Biopolymer Polyphosphate-Manganese into Nanosheets. Small 2022, 18 (41). 27. Sun, P. Q.; Li, K. L.; Lin, K.; Wei, W.; Zhao, J., Ag2S Quantum Dots for Use in Whole-Cell Biohybrid Catalyst for Visible-Light-Driven Photocatalytic Organic Pollutant Degradation. Acs Applied Nano Materials 2022. 28. Chen, Q. Q.; Long, T. F.; Zheng, J.; Sheng, W. J.; Sun, S. S.; Wei, W.; Zhao, J.; Wang, H., Cysteine-Specific Bioconjugation and Stapling of Unprotected Peptides by Chlorooximes. Ccs Chemistry 2022, 4 (10). 29. Xu, Y.; Mo, J. B.; Wei, W.; Zhao, J., Oxidized Black Phosphorus Nanosheets as an Inorganic Antiresorptive Agent. Ccs Chemistry 2021, 3 (4), 1105-1115. 30. Wang, X. Y.; Wei, W.; Zhao, J., Using a Riboswitch Sensor to Detect Co /Ni Transport in. Frontiers in Chemistry 2021, 9. 31. Mo, J. B.; Xu, Y.; Zhu, L. Q.; Wei, W.; Zhao, J., A Cysteine-Mediated Synthesis of Red Phosphorus Nanosheets. Angewandte Chemie-International Edition 2021, 60 (22), 12524-12531. 32. Zhu, Y. L.; Chen, F.; Cheng, D. H.; Chen, Y.; Zhao, X. Y.; Wei, W.; Lu, Y.; Zhao, J., Rhodium(III)-Catalyzed Alkenyl C-H Functionalization to Dienes and Allenes. Organic Letters 2020, 22 (22), 8786-8790. 33. Wang, X. X.; Hu, Y.; Mo, J. B.; Zhang, J. Y.; Wang, Z. Z.; Wei, W.; Li, H. L.; Xu, Y.; Ma, J.; Zhao, J.; Jin, Z.; Guo, Z. J., Arsenene: A Potential Therapeutic Agent for Acute Promyelocytic Leukaemia Cells by Acting on Nuclear Proteins. Angewandte Chemie-International Edition 2020, 59 (13), 5151-5158. 34. Wang, X. X.; Chen, F.; Zhang, J. Y.; Sun, J. X.; Zhao, X. Y.; Zhu, Y. L.; Wei, W.; Zhao, J.; Guo, Z. J., A ferroptosis-inducing iridium(III) complex. Science China-Chemistry 2020, 63 (1), 65-72. 35. Wang, X.; Shi, C. K.; Mo, J. B.; Xu, Y.; Wei, W.; Zhao, J., An Inorganic Biopolymer Polyphosphate Controls Positively Charged Protein Phase Transitions. Angewandte Chemie-International Edition 2020, 59 (7), 2679-2683. 36. Mo, J. B.; Xu, Y.; Wang, X. X.; Wei, W.; Zhao, J., Exploiting the protein corona: coating of black phosphorus nanosheets enables macrophage polarization via calcium influx. Nanoscale 2020, 12 (3), 1742-1748. 37. Han, M. M.; Zhu, L. Q.; Mo, J. B.; Wei, W.; Yuan, B.; Zhao, J.; Cao, C. J., Protein Corona and Immune Responses of Borophene: A Comparison of Nanosheet-Plasma Interface with Graphene and Phosphorene. Acs Applied Bio Materials 2020, 3 (7), 4220-4229. 38. Yan, D. Y.; Jiang, H. M.; Sun, W. X.; Wei, W.; Zhao, J.; Zhang, X. H.; Wu, Y. D., Synthesis of Benzofurans and Benzoxazoles through a [3,3]-Sigmatropic Rearrangement: O-NHAc as a Multitasking Functional Group. Organic Process Research & Development 2019, 23 (8), 1646-1653. 39. Wang, X. X.; Zhang, J. Y.; Zhao, X. Y.; Wei, W.; Zhao, J., Imaging and proteomic study of a clickable iridium complex. Metallomics 2019, 11 (8), 1344-1352. 40. Yan, L.; Sun, P. Q.; Xu, Y.; Zhang, S. B.; Wei, W.; Zhao, J., Integration of a Gold-Specific Whole Cell Sensing and Adsorption Based on BioBrick. International Journal of Molecular Sciences 2018, 19 (12). 41. Yan, D. Y.; Wang, G. Q.; Xiong, F.; Sun, W. Y.; Shi, Z. Z.; Lu, Y.; Li, S. H.; Zhao, J., A selenium-catalysed para-amination of phenols. Nature Communications 2018, 9. 42. Wei, W.; Sun, P. Q.; Li, Z.; Song, K. S.; Su, W. Y.; Wang, B.; Liu, Y. Z.; Zhao, J., A surface-display biohybrid approach to light-driven hydrogen production in air. Science Advances 2018, 4 (2). 43. Wang, X. X.; Zhu, M. L.; Gao, F.; Wei, W.; Qian, Y.; Liu, H. K.; Zhao, J., Imaging of a clickable anticancer iridium catalyst. Journal of Inorganic Biochemistry 2018, 180, 179-185. 44. Wang, X.; Wang, X. M.; Hui, K. M.; Wei, W.; Zhang, W.; Miao, A. J.; Xiao, L.; Yang, L. Y., Highly Effective Polyphosphate Synthesis, Phosphate Removal, and Concentration Using Engineered Environmental Bacteria Based on a Simple Solo Medium-Copy Plasmid Strategy. Environmental Science & Technology 2018, 52 (1), 214-222. 45. Mo, J. B.; Xie, Q. Y.; Wei, W.; Zhao, J., Revealing the immune perturbation of black phosphorus nanomaterials to macrophages by understanding the protein corona. Nature Communications 2018, 9. 46. Cai, S.; Shen, Y. F.; Zou, Y.; Sun, P. Q.; Wei, W.; Zhao, J.; Zhang, C., Engineering highly sensitive whole-cell mercury biosensors based on positive feedback loops from quorum-sensing systems. Analyst 2018, 143 (3), 630-634. 47. Xiong, F.; Lu, L.; Sun, T. Y.; Wu, Q.; Yan, D. Y.; Chen, Y.; Zhang, X. H.; Wei, W.; Lu, Y.; Sun, W. Y.; Li, J. J.; Zhao, J., A bioinspired and biocompatible ortho-sulfiliminyl phenol synthesis. Nature Communications 2017, 8. 48. Wu, Q.; Yan, D. Y.; Chen, Y.; Wang, T.; Xiong, F.; Wei, W.; Lu, Y.; Sun, W. Y.; Li, J. J.; Zhao, J., A redox-neutral catechol synthesis. Nature Communications 2017, 8. 49. Wei, W.; Sun, Y.; Zhu, M. L.; Liu, X. Z.; Sun, P. Q.; Wang, F.; Gui, Q.; Meng, W. Y.; Cao, Y.; Zhao, J., Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB. Journal of the American Chemical Society 2015, 137 (49), 15358-15361. 50. Yang, M. Y.; Jalloh, A. S.; Wei, W.; Zhao, J.; Wu, P.; Chen, P. R., Biocompatible click chemistry enabled compartment-specific pH measurement inside E-coli. Nature Communications 2014, 5. 51. Yang, H. L.; Cui, H. L.; Wang, L. G.; Yan, L.; Qian, Y.; Zheng, X. E.; Wei, W.; Zhao, J., A label-free G-quadruplex DNA-based fluorescence method for highly sensitive, direct detection of cisplatin. Sensors and Actuators B-Chemical 2014, 202, 714-720. 52. Yan, L.; Yan, Y. Y.; Pei, L.; Wei, W.; Zhao, J., A G-quadruplex DNA-based, Label-Free and Ultrasensitive Strategy for microRNA Detection. Scientific Reports 2014, 4. 53. Wei, W.; Liu, X. Z.; Sun, P. Q.; Wang, X.; Zhu, H.; Hong, M.; Mao, Z. W.; Zhao, J., Simple Whole-Cell Biodetection and Bioremediation of Heavy Metals Based on an Engineered Lead-Specific Operon. Environmental Science & Technology 2014, 48 (6), 3363-3371. 54. Wang, D. Q.; Cai, S.; Ben, R.; Zhou, Y.; Li, X. W.; Zhao, J.; Wei, W.; Qian, Y., Direct Access to Isoindolinone Derivatives by Palladium-Catalyzed C-H Activation and Isocyanide Insertion by Using Molecular Oxygen as the Sole Oxidant. Synthesis-Stuttgart 2014, 46 (15), 2045-2050. 55. Wei, W.; Zhu, T. Z.; Wang, Y.; Yang, H. L.; Hao, Z. Y.; Chen, P. R.; Zhao, J., Engineering a gold-specific regulon for cell-based visual detection and recovery of gold. Chemical Science 2012, 3 (6), 1780-1784. 56. Wei, W.; Yang, C.; Luo, J.; Lu, C. M.; Wu, Y. J.; Yuan, S., Synergism between cucumber α-expansin, fungal endoglucanase and pectin lyase. Journal of Plant Physiology 2010, 167 (14), 1204-1210. 获奖情况
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