王秀秀 准聘助理教授

王秀秀，特聘研究员，博士生导师，2014年毕业于浙江大学获硕士学位，2019年毕业于南京大学获博士学位，2019-2021年于南京大学化学化工学院进行博士后研究（导师：郭子建院士）。主要从事无机药物化学生物学研究。目前已发表学术论文40余篇，包括J. Am. Chem. Soc.，Angew. Chem. Int. Ed.，Nat. Commun., ACS nano， Chem. Sci.，Biosens Bioelectron，Sci. China Chem，ACS Appl. Mater. Inter.，Nano Res等，并获国家自然科学基金面上项目、国家重点研发计划青年科学家项目、国家自然科学基金青年基金、江苏省自然科学基金青年基金、中央高校基本科研业务费前沿交叉项目、中国博士后面上基金等项目资助。

邮箱：wangxiuxiu@nju.edu.cn

主要从事无机药物化学生物学研究，具体包括：

（1）精准靶向生物大分子的手性无机金属药物的开发与机制研究；

（2）免疫调控无机药物平台的构建及其生物医药应用研究；

（3）金属中心手性催化药物的开发

主持/参与项目：

国家自然科学基金面上项目

国家重点研发计划青年科学家项目

国家自然科学基金青年项目

江苏省自然科学基金青年基金

中央高校基本科研业务费前沿交叉项目

国家重点研发计划合成生物学专项子课题

中国博士后面上基金等

近五年代表性科研成果：

1. Jing Zhao, Nuo Zhang, Lingfeng Qin, Jingjing Liu, Jing Wang, Yuanfang Xiang, Jiao Zhang, Qingwei Meng, Yong Huang, Chen Lin, Jing Zhao*, Xiuxiu Wang*,Wei Wei*. Reprogramming Bacterial Energetics Reverse Lactate-Mediated Immunosuppression for Synergistic Cancer Immunotherapy. Trends Biotechnol. 2026. Accepted.

2. Lihao Ji, Tianze Zhu, Tianqi Jiang, Li Wang,  Zhonghui Qiu, Shiqi Gao, Yuqi Wang, Jing Wang, Jingyi Zhang, Haomiao Huang, Yunlong Mao, Chen Lin, Jing Zhao*, Xiuxiu Wang*, Wei Wei*. A  live biohybrid bacterial therapy based on engineered Serratia marcescens.  Nat. Commun. 2026. doi: 10.1038/s41467-026-70949-4.

3. Lu  Zhu, Ze Wen, Maokai Yu, Jingyi Zhang, Yue Qin, Shiqi Gao, Yunlong Mao,  Yunfei Deng, Tian Tian, Shengjin Liu, Wenfeng Jiang, Jiajia Ma, Xiaoyong  Wang, Zijian Guo, Wei Wei,* Jing Zhao,* Xiuxiu Wang*. Chirality-Driven Immune Checkpoint Modulation by Chiral Iridium(III) Nanoparticles. J. Am. Chem. Soc. 2026, doi: 10.1021/jacs.6c00020.

4. Li, X*., Zhao, X., Wang, X.,  Xiong, A., Wang, Z., Shi, Z., Zhang, J., Wang, H., Wei, W., He, C., Ma,  J., Guo, Z., Duan, C*.,  Zhao, J*., & Wang, X*. Programmable Modular  Assembly of Homochiral Ir(III)-Metallohelices to Reverse Metallodrug  Resistance by Inhibiting CDK1. Angew Chem Int Ed. 2025，64(7):e202419292.

5. Xinyang Zhao, Xingyun  Wang, Wei Zhang, Tian Tian, Jingyi Zhang, Jing Wang, Wei Wei^*,  Zijian Guo, Jing Zhao^*, Xiuxiu Wang^*. A   Ferroptosis-Inducing Arsenene-Iridium Nanoplatform for Synergistic Immunotherapy in Pancreatic Cancer, Angew. Chem. Int. Ed. 2024, 63(15): e202400829.

6. Jingyi Zhang, Yue Qin,  Yiming Chen, Xinyang Zhao, Jing Wang, Zhenzhen Wang, Jiayi Li, Jing Zhao,  Shengjin Liu, Zijian Guo, Wei Wei^*, Jing Zhao^*, Xiuxiu  Wang^*. Ultrathin 2D As2Se3 Nanosheets for  Photothermal-Triggered Cancer Immunotherapy, ACS Nano, 2024, 18(5): 4398-4413.

7. Lu Zhu, Xingyun Wang,      Tian Tian, Yanyan Chen, Wenjing Du, Wei Wei^*, Jing Zhao^*,  Zijian Guo and Xiuxiu Wang^*, A      Λ-Ir(iii)-phenylquinazolinone complex enhances ferroptosis by selectively inhibiting metallothionein-1. Chem. Sci. 2024, 15, 10499.

8. Jing Zhao, Chen Wang, Jingjing Liu, Nuo Zhang, Yuqin Zhao, Jing Zhao^*, Xiuxiu Wang^*, Wei Wei^*, A biocompatible surface display approach in Shewanella promotes current output efficiency. Biosens  Bioelectron. 2024, 259, 116422.

9. Xuezhao Li^*,  Zhicheng Wang, Xiaorou Hao, Jingyi Zhang, Xing Zhao, Yougang Yao, Wei Wei, Rui Cai, Cheng He, Chunying Duan^*, Zijian Guo, Jing Zhao^*, Xiuxiu Wang^*. Optically Pure Double-Stranded Dinuclear Ir(III) Metallohelices Enabled Chirality-Induced Photodynamic Responses. J Am Chem Soc. 2023, 145, 14766.

10. Xinyang Zhao, Jingyi Zhang, Wei Zhang, Zijian Guo, Wei Wei^*, Xiuxiu Wang^* and Jing Zhao^*. A chiral fluorescent Ir(III) complex that targets the GPX4 and ErbB pathways to induce cellular Ferroptosis. Chem. Sci. 2023, 14, 1114.

11. Jingyi Zhang, Yue Qin,  Zhicheng Wang, Wei Zhang, Shengjin Liu, Wei Wei^*, Xiuxiu Wang^*, Jing Zhao^*. Ferroptosis-inducing      Inorganic Arsenic (II) Sulfide Nanocrystals Enhance Immune Activation.  Nano Res. 2023. 16, 9760.

12. Lu Zhu, Wenjing Du, Yanrong Li^*, Ding Li, Wei Wei^*, Jing Zhao^*, and Xiuxiu Wang^*. Chiral SPINOL-Based Pt(II)      Metallacycles For Immunogenic Cell Death. Inorg. Chem. 2023. 62, 14922.

13. Yanyan Chen, Hao Jiang, Tingting Hao, Nan Zhang, Mingyu Li, Xingyun Wang, Xiuxiu Wang^*,  Wei Wei^*, and Jing Zhao^*. Fluorogenic Reactions in Chemical Biology: Seeing Chemistry in Cells.  Chem. Biomed.  Imaging. 2023, 1, 7, 590.

14. X Wang, J Zhang, Y Hu, X Zhao, Z Wang, J Liang, W Yu, T Tian, H Zhou, J Li, S Liu, J Zhao^*, Z Jin^*, W Wei^*, Z Guo^*. Multi-Omics Analysis Reveals the Unexpected Immune Regulatory Effects of Arsenene Nanosheets in Tumor Microenvironment. ACS Appl. Mater. Interfaces. 2022, 14, 45137.

15. Wang X, Han Z, Wei W, Hu H, Li  P, Sun P, Liu X, Lv Z, Wang F, Cao Y, Guo Z^*, Li J^*,  Zhao J^*. An unexpected all-metal aromatic tetranuclear silver cluster in human copper chaperone Atox1. Chem. Sci. 2022, 13, 7269.

16. Wang, X, Hu, Y, Mo, J, Zhang, J, Wang, Z, Wei, W, Li, H, Xu, Y, Ma, J, Zhao, J^*, Jin, Z^*,  Guo, Z^*. Arsenene: A Potential Therapeutic Agent for Acute Promyelocytic Leukaemia Cells by Acting on Nuclear Proteins. Angew. Chem. Int. Ed. 2020, 59, 5151-5158.

17. Wang X, Chen F, Zhang J, Sun J,  Zhao X, Zhu Y, Wei W^*, Zhao J^*, Guo Z^*. A  ferroptosis-inducing iridium (III) complex. Sci China Chem. 2020, 63, 65–72.