个人简介
南京大学生命科学学院教授、博导，主要从事进化遗传学、生物信息学相关研究。
研究方向
主要从事进化遗传学、生物信息学研究方向： （1）基因组遗传变异的分子机制； （2）植物抗病基因的起源、遗传变异与保存机制、功能等； （3）基因组学、功能基因组学；
代表性研究论文：
Wang L, Ho AT, Hurst LD*, Yang S*. (2023) Re-evaluating evidence for adaptive mutation rate variation. Nature 619: E52-56 Jia Y, Qin C, Traw MB, Chen X, He Y, Kai J, Yang S*, Wang L*, Hurst LD* (2022) In rice splice variants that restore the reading frame after frameshifting indel introduction are common, often induced by the indels and sometimes lead to organism-level rescue. PLOS Genetics 18(2): e1010071 Ren Y, He Z, Liu P, Traw B, Sun S, Tian D, Yang S, Jia Y, Wang L*. (2021) Somatic mutation analysis in Salix suchowensis reveals early segregated cell lineages. Mol Biol Evol DOI：10.1093/molbev/msab286 Yu L, Ma S, Zhang X, Tian D, Yang S*, Jia X*, Traw MB*. (2021) Rapid functional differentiation and fixation of the duplicated members in rice Dof genes after whole genome duplication. Plant J 108：1351-1381 Jia X, Zhang Q, Jiang M, Huang J, Yu L, Traw MB, Tian D, Hurst LD*, Yang S* (2021) Mitotic gene conversion can be as important as meiotic conversion in driving genetic variability in plants and other species without early germline segregation. PLOS Biol19(3): e3001164
Wang L, Sun, Y, Sun X, Yu L, Xue L, He Z, Huang J, Tian D, Hurst LD*, Yang S* (2020) Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life. Genome Biol21:142
Jiang M, He Y, Chen X, Zhang X, Guo Y, Yang S, Huang J, Traw M* (2020) CRISPR-based assessment of genomic structure in the conserved SQUAMOSA promoter-binding-like gene clusters in rice. Plant J 104(5):1301-1314
Wang L, Zhao L, Zhang X, Zhang Q, Jia Y, Wang G, Li S, Tian D, Li WS*, Yang S* (2019) Large-scale identification and functional analysis of NLR genes in blast resistance in the Tetep rice genome sequence. PNAS 116:18479-18487
Chen J, Hao Z, Guang X, Zhao C, Wang P, Xue L, Zhu Q, Yang L, Yu Sheng1 , Zhou Y, Xu H, Xie H, Long X, Zhang J, Wang Z, Shi M, Lu Y, Liu S, Guan L, Zhu Q, Yang L, Ge S , Cheng T, Laux T, Gao Q, Peng Y, Liu N*, Yang S*, Shi J* (2019) Liriodendron genome sheds light on angiosperm phylogeny and species-pair differentiation. Nature Plants5：18–25
Wang L, Ji Y, Hu Y, Hu H, Jia X, Jiang M, Zhang X, Zhao L, Zhang Y, Jia Y, Qin C, Yu L, Huang J, Yang S*, Hurst LD* and Tian D*. (2019) The architecture of intra-organism mutation rate variation in plants. Plos Biol 17(4):e3000191
Jia X, Zhang Y, Zhang Q, Zhao Q, Wang L, Traw M, Tian D, Wang C*, Yang S*. (2019) High resolution insight into recombination events at the SD1 locus in rice. Plant J 97：683-692
Chen X, Tian X, Xue L, Zhang X, Yang S*, Traw M*, Huang J*. (2019) CRISPR-based assessment of gene specialization in the gibberellin metabolic pathway in rice. Plant Physiol180(4):2091-2105
Liu H, Huang J, Sun X, Li J, Hu Y, Yu L,Liti G, Tian D, Hurst LD*, Yang S*. (2018) Tetrad analysis in plants and fungifinds large differences in gene conversion rates but no GC bias. Nature Ecol Evol 2, 164–173
Huang J, Li J, Zhou J, Wang L, Yang S, Hurst LD, Li W-H* & Tian D*. (2018) Identifying a Large Number of High-Yield Genes in Rice by Pedigree Analysis, Whole-Genome Sequencing, and CRISPR-Cas9 Gene Knockout. PNAS 115(32): E7559-E7567
Liu H, Jia Y, Sun X, Tian D, Hurst LD*,Yang S*. (2017) Direct determination of the mutation rate in the bumblebeereveals evidence for weak recombination-associated mutation and an approximaterate constancy in insects. Mol Biol Evol 34: 119-130
Gu L, Wu Y, Jiang M, Si W, Zhang X, TianD*, Yang S*. (2016) Dissimilar Manifestation of Heterosis in Super Hybrid Riceat Early-Tillering Stage under Nutrient-Deficient and Nutrient-SufficientCondition. Plant Physiol 172: 1142-1153
Xie Z, Wang L, Wang L, Wang Z, Lu, Z, TianD, Yang S*, Hurst LD.* (2016) Mutation rate analysis via parent-progenysequencing of the perennial peach I. A low rate in woody perennials and ahigher mutagenicity in hybrids. P Roy Soc B-Biol Sci 283: 20161016.
Wang L, Zhang Y, Qing C, Tian D, Yang S*,Hurst LD.* Mutation rate analysis via parent-progeny sequencing of theperennial peach II: No evidence for recombination-associated mutation. P RoySoc B-Biol Sci 283: 20161785 Sun XQ, Li DH, Xue JY, Yang SH, Zhang YM, Li MM, Hang Y. (2016) Insertion DNA accelerates meiotic inerchromosomal recombination in Arabidopsis thaliana. Mol Biol Evol 33:2044-53
Yang S, Wang L, Huang J, Zhang X, Yuan Y,Chen J-Q, Hurst LD*, Tian D* (2015). Parent-progeny sequencing indicates highermutation rates in heterozygotes. Nature 523 :463-467
Liu H#, Zhang X#, Huang J, Chen JQ, Tian D,Hurst LD*, Yang S*. (2015) Causes and consequences of crossing-over evidencedvia a high-resolution recombinational landscape of the honey bee. Genome Biology16:15
Si W, Yuan Y, Huang J, Zhang X, Zhang Y,Zhang Y, Tian D, Wang C, Yang YH*, Yang S*. (2015) Widely distributed hot andcold spots in meiotic recombination as shown by sequencing of rice F2 plants. New Phytologist 206 :1491-1502
Zhang X#, Yang S#, Wang J#, Jia Y#, HuangJ#, Zhong Y, Tan S, Wang L, Gu L, Chen JQ, Pan QH*, Bergelson J*, Tian D*.(2015) A genome-wide survey reveals abundant rice blast R-genes in resistantcultivars. Plant J 84 :20-28 Yang S#, Li J#, Zhang X#, Zhang Q, Huang J,Chen J-Q, Hartl DL*, Tian D*. (2013) Rapidly evolving R genes in diverse grassspecies confer resistance to rice blast disease. PNAS110:18572-18577.
Yang S#, Yuan Y#, Wang L#, Li J, Wang W,Liu H, Chen JQ, Hurst LD*, Tian D*. (2012) Great majority of recombinationevents in Arabidopsis are gene conversion events. PNAS 109:20992–20997.
Yue J-X, Meyers BC, Chen J-Q, Tian D*, YangS*. (2012) Tracing the origin and evolutionary history of plantnucleotide-binding site-leucine-rich repeat (NBS-LRR) genes. New Phytologist 193: 1049–1063.
Tian D, Wang Q, Zhang P, Araki H, Yang S, Kreitman M, Nagylaki T, Hudson R, Bergelson J & Chen JQ. (2008) Single-nucleotide mutation rate increases close to indels in eukaryotes. Nature 455:105-108
科研成果
Wang L, Ho AT, Hurst LD*, Yang S*. (2023) Re-evaluating evidence for adaptive mutation rate variation. Nature 619: E52-56
Jia Y, Qin C, Traw MB, Chen X, He Y, Kai J, Yang S*, Wang L*, Hurst LD* (2022) In rice splice variants that restore the reading frame after frameshifting indel introduction are common, often induced by the indels and sometimes lead to organism-level rescue. PLOS Genetics 18(2): e1010071 Ren Y, He Z, Liu P, Traw B, Sun S, Tian D, Yang S, Jia Y, Wang L*. (2021) Somatic mutation analysis in Salix suchowensis reveals early segregated cell lineages. Mol Biol Evol DOI：10.1093/molbev/msab286 Yu L, Ma S, Zhang X, Tian D, Yang S*, Jia X*, Traw MB*. (2021) Rapid functional differentiation and fixation of the duplicated members in rice Dof genes after whole genome duplication. Plant J 108：1351-1381 Jia X, Zhang Q, Jiang M, Huang J, Yu L, Traw MB, Tian D, Hurst LD*, Yang S* (2021) Mitotic gene conversion can be as important as meiotic conversion in driving genetic variability in plants and other species without early germline segregation. PLOS Biol19(3): e3001164 Wang L, Sun, Y, Sun X, Yu L, Xue L, He Z, Huang J, Tian D, Hurst LD*, Yang S* (2020) Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life. Genome Biol21:142 Jiang M, He Y, Chen X, Zhang X, Guo Y, Yang S, Huang J, Traw M* (2020) CRISPR-based assessment of genomic structure in the conserved SQUAMOSA promoter-binding-like gene clusters in rice. Plant J 104(5):1301-1314 Wang L, Zhao L, Zhang X, Zhang Q, Jia Y, Wang G, Li S, Tian D, Li WS*, Yang S* (2019) Large-scale identification and functional analysis of NLR genes in blast resistance in the Tetep rice genome sequence. PNAS 116:18479-18487 Chen J, Hao Z, Guang X, Zhao C, Wang P, Xue L, Zhu Q, Yang L, Yu Sheng1 , Zhou Y, Xu H, Xie H, Long X, Zhang J, Wang Z, Shi M, Lu Y, Liu S, Guan L, Zhu Q, Yang L, Ge S , Cheng T, Laux T, Gao Q, Peng Y, Liu N*, Yang S*, Shi J* (2019) Liriodendron genome sheds light on angiosperm phylogeny and species-pair differentiation. Nature Plants5：18–25 Wang L, Ji Y, Hu Y, Hu H, Jia X, Jiang M, Zhang X, Zhao L, Zhang Y, Jia Y, Qin C, Yu L, Huang J, Yang S*, Hurst LD* and Tian D*. (2019) The architecture of intra-organism mutation rate variation in plants. Plos Biol 17(4):e3000191 Jia X, Zhang Y, Zhang Q, Zhao Q, Wang L, Traw M, Tian D, Wang C*, Yang S*. (2019) High resolution insight into recombination events at the SD1 locus in rice. Plant J 97：683-692 Chen X, Tian X, Xue L, Zhang X, Yang S*, Traw M*, Huang J*. (2019) CRISPR-based assessment of gene specialization in the gibberellin metabolic pathway in rice. Plant Physiol180(4):2091-2105 Liu H, Huang J, Sun X, Li J, Hu Y, Yu L,Liti G, Tian D, Hurst LD*, Yang S*. (2018) Tetrad analysis in plants and fungifinds large differences in gene conversion rates but no GC bias. Nature Ecol Evol 2, 164–173 Huang J, Li J, Zhou J, Wang L, Yang S, Hurst LD, Li W-H* & Tian D*. (2018) Identifying a Large Number of High-Yield Genes in Rice by Pedigree Analysis, Whole-Genome Sequencing, and CRISPR-Cas9 Gene Knockout. PNAS 115(32): E7559-E7567 Liu H, Jia Y, Sun X, Tian D, Hurst LD*,Yang S*. (2017) Direct determination of the mutation rate in the bumblebeereveals evidence for weak recombination-associated mutation and an approximaterate constancy in insects. Mol Biol Evol 34: 119-130 Gu L, Wu Y, Jiang M, Si W, Zhang X, TianD*, Yang S*. (2016) Dissimilar Manifestation of Heterosis in Super Hybrid Riceat Early-Tillering Stage under Nutrient-Deficient and Nutrient-SufficientCondition. Plant Physiol 172: 1142-1153 Xie Z, Wang L, Wang L, Wang Z, Lu, Z, TianD, Yang S*, Hurst LD.* (2016) Mutation rate analysis via parent-progenysequencing of the perennial peach I. A low rate in woody perennials and ahigher mutagenicity in hybrids. P Roy Soc B-Biol Sci 283: 20161016. Wang L, Zhang Y, Qing C, Tian D, Yang S*,Hurst LD.* Mutation rate analysis via parent-progeny sequencing of theperennial peach II: No evidence for recombination-associated mutation. P RoySoc B-Biol Sci 283: 20161785 Sun XQ, Li DH, Xue JY, Yang SH, Zhang YM, Li MM, Hang Y. (2016) Insertion DNA accelerates meiotic inerchromosomal recombination in Arabidopsis thaliana. Mol Biol Evol 33:2044-53 Yang S, Wang L, Huang J, Zhang X, Yuan Y,Chen J-Q, Hurst LD*, Tian D* (2015). Parent-progeny sequencing indicates highermutation rates in heterozygotes. Nature 523 :463-467 Liu H#, Zhang X#, Huang J, Chen JQ, Tian D,Hurst LD*, Yang S*. (2015) Causes and consequences of crossing-over evidencedvia a high-resolution recombinational landscape of the honey bee. Genome Biology16:15 Si W, Yuan Y, Huang J, Zhang X, Zhang Y,Zhang Y, Tian D, Wang C, Yang YH*, Yang S*. (2015) Widely distributed hot andcold spots in meiotic recombination as shown by sequencing of rice F2 plants. New Phytologist 206 :1491-1502 Zhang X#, Yang S#, Wang J#, Jia Y#, HuangJ#, Zhong Y, Tan S, Wang L, Gu L, Chen JQ, Pan QH*, Bergelson J*, Tian D*.(2015) A genome-wide survey reveals abundant rice blast R-genes in resistantcultivars. Plant J 84 :20-28 Yang S#, Li J#, Zhang X#, Zhang Q, Huang J,Chen J-Q, Hartl DL*, Tian D*. (2013) Rapidly evolving R genes in diverse grassspecies confer resistance to rice blast disease. PNAS110:18572-18577. Yang S#, Yuan Y#, Wang L#, Li J, Wang W,Liu H, Chen JQ, Hurst LD*, Tian D*. (2012) Great majority of recombinationevents in Arabidopsis are gene conversion events. PNAS 109:20992–20997. Yue J-X, Meyers BC, Chen J-Q, Tian D*, YangS*. (2012) Tracing the origin and evolutionary history of plantnucleotide-binding site-leucine-rich repeat (NBS-LRR) genes. New Phytologist 193: 1049–1063. Tian D, Wang Q, Zhang P, Araki H, Yang S, Kreitman M, Nagylaki T, Hudson R, Bergelson J & Chen JQ. (2008) Single-nucleotide mutation rate increases close to indels in eukaryotes. Nature 455:105-108
获奖情况
2020年第十一届梁希林业科学技术奖自然科学奖二等奖 2018年度高校科学研究优秀成果奖自然科学一等奖 2017年科技部“创新人才推进计划”中青年科技创新领军人才 （科技部） 2015年入选江苏省“六大人才高峰”第十二批高层次人才支持计划 2014年入选南京大学第二批“登峰人才支持计划” 2013年江苏省教学成果奖（高等教育类）一等奖 2012年度教育部“新世纪优秀人才支持计划” 2010年度江苏省高校“青蓝工程”中青年学术带头人培养对象
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