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杨雪梅 准聘副教授

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电子邮件： xuemei.yang@nju.edu.cn

个人主页：

  • 个人简介
  • 科研成果
  • 获奖情况

个人简介

杨雪梅，南京大学生命科学学院准聘副教授/特聘研究员，至诚青年教授，博导，国家级青年人才计划入选者。主要从事病原菌耐药和致病机制以及新型抗菌疗法的研究。以第一作者在Nat Microbiol、Trends Microbiol、J Infect、ACS Central Science、eBioMedcine和Emerg Microbes Infect等期刊发表论文20余篇，参与著作1项，申请发明专利1项。

研究方向

综合运用分子流行病学和免疫学的策略，挖掘病原菌抗原靶点，研究病原菌与宿主互作和免疫逃逸机制，开发更有效和可行的免疫治疗策略，以应对重要病原菌感染。

（1）病原菌的分子流行病学特征和抗原靶点挖掘

（2）病原菌与宿主互作的分子机制及免疫逃逸机制

（3）基于分子流行病学和病原菌-宿主互作的免疫治疗方法


欢迎对本实验室研究方向感兴趣的本科生、研究生、博士后、科研助理及副研究员加入，有意者可发邮件至：xuemei.yang@nju.edu.cn。

学术兼职

工作经历

科研成果

26. Wang, J.#, Yang, X.#, Huang, Z.#, Su, Y., Zhang, X., Song, N., Wang, P., Yang, C., Cao, H., Liu, X.-W., Li, X.*, Chen, S.* & Li, M.* (2025). Synthesis of Campylobacter jejuni capsular oligosaccharides and identification of a potential O-antigen against campylobacteriosis. Science Advances.11(15), eadu2318.

25. Yang, X., Zhang, H., Tang, Y., Heng, H.,Cheung, YC., Song, X.,Kong, HK., Chan, E. W.-C., Zhang, R. & Chen, S.* (2024). Functional relay between Mph(A) enzyme and Mrx efflux pump mediates azithromycin resistance, a novel mechanism of bacterial antimicrobial resistance. Drug Resistance Updates. 77, 101127.

24. Yang, X., Wei, R., Liu, H., Wei, T., Zeng, P., Cheung, Y. C., Heng, H., Chan, E. W., Li, X.* & Chen, S.* (2024). Discovery of a monoclonal antibody that targets cell-surface Pseudaminic acid of Acinetobacter baumannii with direct bactericidal effect. ACS Central Science. 10(2), 439-446.

23. Yang, X., Man, M.-Y., Heng, H., Chan, B. K.-W., Hu, Q., Chan, E. W.-C., Shum, H.-P.* & Chen, S.* (2024). Molecular epidemiology and clinical impact of Klebsiella spp. causing bloodstream infections in Hong Kong. EBioMedicine. 101, 104998.

22. Yang, X., Zhang, H., Chan, E. W.-C., Zhang, R. & Chen, S.* (2024). Transmission of azithromycin-resistant gene, erm(T), of Gram-positive bacteria origin to Klebsiella pneumoniae. Microbiological Research. 282, 127636.

21.Heng, H.#, Yang, X.#, Zhang, H., Sun, R.,Ye, L., Li, J.,Chan, E. W.-C., Zhang, R. & Chen, S.*(2024). Early detection of OXA-232-producing Klebsiella pneumoniae in China predating its global emergence. Microbiological Research. 282, 127672.

20. Cheung, YC.#, Guo, X.#, Yang, X.#, Wei, R., Chan, E. WC., Li, X.*, Chen, S.* (2024). KpsS1 Mediates the Glycosylation of Pseudaminic Acid in Acinetobacter Baumannii. Chemistry. 30(41), e202400703

19. Yang, X., Liu, X., Chan, E. W., Zhang, R. & Chen, S.* (2023). Functional characterization of plasmid-borne rmpADC homologues in Klebsiella pneumoniae. Microbiology Spectrum. 11 (3), e0308122.1.

18. Yang, X., Sun, Q., Li, J., Jiang, Y., Li, Y., Lin, J., Chen, K., Chan, E. W-C., Zhang, R.*, & Chen, S.* (2022). Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae in China. Emerging Microbes and Infections. 11(1), 841-849.

17. Sun Q.#, Yang X.#, Huang Y., Li Y., Lin J., He D., Liu C., Chen S.*, Zhang R.* (2022). Risk factors and clinical impact associated with infections caused by different types of carbapenem-resistant Klebsiella pneumoniae in China: A clinical study from 2014∼2017. Journal of Infection. 85, 4, 473-476. 

16. Yang, X., Liu, X., Xu, Y., Chan, E. W., Zhang, R. & Chen, S.* (2022). An IncB/O/K/Z conjugative plasmid encodes resistance to azithromycin and mediates transmission of virulence plasmid in Klebsiella pneumoniae. International Journal of Antimicrobial Agents. 60, 5-6, 106683.

15. Yang, X., Xie, M., Xu, Q., Ye, L., Yang, C., Dong, N., Chan, E. W-C., Zhang, R., & Chen, S.* (2022). Transmission of pLVPK-like virulence plasmid in Klebsiella pneumoniae mediated by an Incl1 conjugative helper plasmid. iScience. 25(6), 104428.

14. Yang, X., Liu, X., Xu Y., Yang, C., Chan, E. W-C., Shum H., Chen, S.* (2022). Genetic and functional characterization of a conjugative KpVP-2 type virulence plasmid from a clinical Klebsiella pneumoniae strain. Frontiers in Microbiology. 13, 914884.

13. Wu, Y.#, Yang, X.#, Liu, C., Zhang, Y., Cheung, Y. C., Chan, E. W. C., Chen, S.*, & Zhang, R.* (2022). Identification of a KPC variant conferring resistance to ceftazidime-avibactam from ST11 carbapenem-resistant Klebsiella pneumoniae strains. Microbiology Spectrum. 10(2), e0265521.

12. Yang, X., Liu, X., Yang, C., Chan, E. W-C., Zhang, R., & Chen, S.* (2021). A conjugative IncI1 plasmid carrying erm(B) and blaCTX-M-104 that mediates resistance to azithromycin and cephalosporins. Microbiology Spectrum. 9(2), 9, e0028621.

11.Yang, X., Ye, L., Chan, E. W-C., Zhang, R., & Chen, S.* (2021). Characterization of an IncFIB/IncHI1B plasmid encoding efflux pump TMexCD1-TOprJ1 in a clinical tigecycline- and carbapenem-resistant Klebsiella pneumoniae strain. Antimicrobial Agents and Chemotherapy. 65(4), e02340-20.

10. Yang, X., Dong, N., Chan, E. W-C., Zhang, R., & Chen, S.* (2021). Carbapenem Resistance-Encoding and Virulence-Encoding Conjugative Plasmids in Klebsiella pneumoniae. Trends in Microbiology. 29(1), 65-83.

9. Yang, X., Dong, N., Liu, X., Yang, C., Ye, L., Chan, E. W-C., Zhang, R., & Chen, S.* (2021). Co-conjugation of virulence plasmid and KPC plasmid in a clinical Klebsiella pneumoniae strain. Frontiers in Microbiology. 12, 739461.

8. Wei, R.#, Yang, X.#, Liu, H., Wei, T., Chen, S.,* & Li, X.* (2021). Synthetic Pseudaminic-acid-based antibacterial vaccine confers effective protection against Acinetobacter baumannii infection. ACS Central Science. 7(9), 1535-1542.

7. Xie, M.#, Yang, X.#, Xu, Q., Ye, L., Chen, K., Zheng, Z., Dong, N., Sun, Q., Shu, L., Gu, D., Chan, E. W-C., Zhang, R.*, & Chen, S.* (2021). Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae. Communications Biology. 4, 650. 

6. Yang, X.#, Dong, N.#, Chan, E. W-C., & Chen, S.* (2020). Genetic cluster analysis of SARS-CoV-2 and the identification of those responsible for the major outbreaks in various countries. Emerging Microbes and Infections. 9(1), 1287-1299.

5. Yang, X., Ye, L., Chan, E. W-C., Zhang, R., & Chen, S.* (2020). Tracking recombination events that occur in conjugative virulence plasmid p15WZ-82_Vir during the transmission process. mSystems. 5(4), e00140-20.

4. Yang, X., Ye, L., Li, Y., Chan, E. W-C., Zhang, R.*, & Chen, S.* (2020). Identification of a chromosomal integrated DNA fragment containing the rmpA2 and iucABCDiutA virulence genes in Klebsiella pneumoniae. mSphere. 5(6), e01179-20.

3. Yang, X., Chan, E. W-C., Zhang, R., & Chen, S.* (2019). A conjugative plasmid that augments virulence in Klebsiella pneumoniae. Nature Microbiology. 4(12), 2039-2043.

2. Yang, X., Li, S., Wu, Y., Yu, W., & Han, F.* (2016). Cloning and characterization of two thermo- and salt-tolerant oligoalginate lyases from marine bacterium Halomonas sp. FEMS Microbiology Letters, 363(9). doi:10.1093/femsle/fnw079

1. Li, S.#, Yang, X.#, Bao, M., Wu, Y., Yu, W., & Han, F.* (2015). Family 13 carbohydrate-binding module of alginate lyase from Agarivorans sp. L11 enhances its catalytic efficiency and thermostability, and alters its substrate preference and product distribution. FEMS Microbiol Lett, 362(10). doi:10.1093/femsle/fnv054

获奖情况