生命科学学院

科研成果

代表性论文

1)Harnessing the power of microbes: Enhancing soybean growth in an acidic soil through AMF inoculation rather than P-fertilization. Horticulture Research, 2024, 11(5): uhae067.https://doi.org/10.1093/hr/uhae067

2)A modified natural small molecule inhibits triple-negative breast cancer growth by interacting with Tubb3. Phytomedicine, 2024, 126: 154894. https://doi.org/10.1016/j.phymed.2023.154894

3)Unveiling the hidden world: How arbuscular mycorrhizal fungi and its regulated core fungi modify the composition and metabolism of soybean rhizosphere microbiome. Environmental Microbiome, 2024, 19: 78. https://doi.org/10.1186/s40793-024-00624-y

4)Impact of dual Bt-transgenic maize (2A7) on soil microbial communities and enzyme activities: A comparative study with control variety Z58. Environmental Research, 2024, 263: 120006. https://doi.org/10.1016/j.envres.2024.120006

5)In vivo transgenic studies confirm the critical acylation function of LeBAHD56 for shikonin in Lithospermum erythrorhizon. Plant Cell Reports, 2024, 43: 160. https://doi.org/10.1007/s00299-024-03242-7

6)Triple-transgenic soybean in conjunction with glyphosate drive patterns in the rhizosphere microbial community assembly. Environmental Pollution, 2023, 335: 122337. https://doi.org/10.1016/j.envpol.2023.122337

7)Mycorrhizae enhance soybean plant growth and Al stress tolerance by shaping the microbiome assembly in an acidic soil. Microbiology Spectrum, 2023, 11(2): e03310-22. https://doi.org/10.1128/spectrum.03310-22

8)Discrepancies in rhizobacterial assembly caused by glyphosate application and herbicide-tolerant soybean co-expressing GAT and EPSPS. Journal of Hazardous Materials, 2023, 450: 131053. https://doi.org/10.1016/j.jhazmat.2023.131053

9)PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism. European Journal of Medicinal Chemistry, 2023, 249: 115166. https://doi.org/10.1016/j.ejmech.2023.115166

10)紫草素-中药植物天然产物: 生物合成、遗传调控、结构修饰与医药功能. 中国科学·生命科学, 2022, 52 (3): 347-372. https://doi.org/10.1360/SSV-2021-0152

11)The host niches of soybean rather than genetically modification or glyphosate application drive the assembly of root-associated microbial communities. Microbial Biotechnology, 2022, 15(12): 2942–2957. https://doi.org/10.1111/1751-7915.14164

12)Anti-microbial efficacy, mechanisms and druggability evaluation of the natural flavonoids. Journal of Applied Microbiology, 2022, 133(3): 1975–1988. https://doi.org/10.1111/jam.15705

13)Functional modulation of an aquaporin to intensify photosynthesis and abrogate bacterial virulence in rice. Plant Journal, 2021, 108(2): 330-346. https://doi.org/10.1111/tpj.15427

14)Changes of microbial functional capacities in the rhizosphere contribute to aluminum tolerance by genotype-specific soybeans in acid soils. Biology and Fertility of Soils, 2020, 56(6): 771-783. https://doi.org/10.1007/s00374-020-01451-2

15)Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo. Chinese Medicine, 2020, 15: 23. https://doi.org/10.1186/s13020-020-00305-1

16)Naphthoquinones: a continuing source for discovery of therapeutic antineoplastic agents. Chemical Biology & Drug Design, 2018, 91(3): 681-690. https://doi.org/10.1111/cbdd.13141

17)Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors. European Journal of Medicinal Chemistry, 2018, 144: 137-150. https://doi.org/10.1016/j.ejmech.2017.12.019

18)Identification of new shikonin derivatives as STAT3 inhibitors. Biochemical Pharmacology, 2017, 146: 74-86. https://doi.org/10.1016/j.bcp.2017.10.009

19)Transgenic analysis reveals LeACS-1 as a positive regulator of ethylene-induced shikonin biosynthesis in Lithospermum erythrorhizon hairy roots. Plant Molecular Biology, 2016, 90(4-5): 345-358. https://doi.org/10.1007/s11103-015-0421-z

20)Widely distributed hot and cold spots in meiotic recombination as shown by the sequencing of rice F2 plants. New Phytologist, 2015, 206(4): 1491–1502. https://doi.org/10.1111/nph.13319

21)Synthesis of aryl dihydrothiazol acyl shikonin ester derivatives as anticancer agents through microtubule stabilization. Biochemical Pharmacology, 2015, 96(2): 93-106. http://doi.org/10.1016/j.bcp.2015.04.021

22)转基因作物对土壤微生物群落的影响及主要研究策略. 农业生物技术学报, 2011, 19 (1): 1-8. http://doi.org/10.3969/j.issn.1674-7968.2011.01.001

23)1,3,4-thiadiazole: synthesis, reactions, and applications in medicinal, agricultural, and materials chemistry. Chemical Reviews, 2014, 114 (10): 5572–5610. https://doi.org/10.1021/cr400131u

24)Nitric oxide regulates shikonin formation in suspension cultured Onosma paniculatum cells. Plant and Cell Physiology, 2009, 50(1): 118-128. https://doi.org/10.1093/pcp/pcn178

25)Impacts of methamidophos on biochemical, physiological, and genetic characteristics of soil microbial communities. Soil Biology & Biochemistry, 2008, 40(3):778-788.https://doi.org/10.1016/j.soilbio.2007.10.012

26)A mtochondrial magnesium transporter functions in Arabidopsis pollen development. Molecular Plant, 2008, 1(4): 675-685. https://doi.org/10.1093/mp/ssn031

27)Engineered external guide sequences are highly effective in inducing RNase P for inhibition of gene expression and replication of human cytomegalovirus. Nucleic Acids Research, 2006, 34(2): 575-583. https://doi.org/10.1093/nar/gkj431

28)Effects of agricultural chemicals on DNA sequence diversity of soil microbial communities: a study with RAPD marker. Microbial Ecology, 2000, 39(1): 72-79. https://doi.org/10.1007/s002489900180

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杨永华教授

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杨永华 教授

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杨永华教授