张峰 准聘副教授

南京大学生命科学学院准聘副教授，江苏特聘教授，2025年入选国家级青年人才计划。长期以小鼠与人脑类器官为模型，从事哺乳动物神经发育调控的分子机制及脑发育相关疾病的病理机制研究。围绕神经发育的表观遗传学调控、脑发育疾病的分子病理机制以及病毒致畸机制等方向，取得了多项研究成果。目前已以（含共一）第一作者在 Science、Cell Stem Cell (2篇)、PNAS、Nature Communications、Molecular Psychiatry、JBC、eBioMedicine 等期刊发表论文11篇，合作论文18篇。

 工作经历：

(1)  2025-12 至今，南京大学，准聘副教授

(2) 2024-8 至2025-11，南京大学，准聘助理教授

(3) 2022-12 至 2024-7, 宾夕法尼亚大学, 佩雷尔曼医学院, Research Associate

(4) 2017-12 至 2022-11, 宾夕法尼亚大学, 佩雷尔曼医学院, 博士后

教育经历：

(1) 2010-09 至 2018-01, 中国科学院遗传与发育生物学研究所, 细胞生物学, 博士

(2) 2006-09 至 2010-06, 山东大学, 生物科学, 学士

大脑是机体最复杂的器官，由近千亿形态、功能各异的神经细胞及其突触连接构成，形成高度复杂的神经网络，调控学习、记忆、情感与运动等生理和心理活动。神经细胞起源于大脑发育过程，经神经前体（干）细胞的增殖、分化、迁移和成熟，生成各类神经元，构建起完整的神经系统。神经发育过程受精密调控，但易受多种遗传因素（如风险基因突变）或环境因素（如病毒感染）影响，从而导致神经发育紊乱，进而引发一系列神经发育疾病，包括小颅畸形、智力低下、孤独症等。

表观转录组，即RNA上的化学修饰，在调节RNA代谢（如剪切、降解、翻译、折叠等）以及多种生物学过程（如发育、衰老、肿瘤等）中起着至关重要的作用。RNA修饰相关蛋白的突变或异常表达、RNA修饰水平的异常变化也与多种人类疾病（包括神经发育疾病）密切相关。例如，调节mRNA m⁶A修饰的多个基因在神经系统的特异性敲除会严重影响神经前体细胞的分化、存活与神经发生；在人类智力低下、小颅畸形等脑发育疾病的有关病例报道中，已发现了近二十个RNA修饰相关基因的突变与疾病相关。此外，RNA修饰的研究具有巨大的应用价值，宾夕法尼亚大学的卡塔林·卡里科和德鲁·魏斯曼教授因为利用RNA化学修饰而开发出有效的新冠病毒mRNA疫苗，获得了2023年诺贝尔生理学或医学奖。

十几年前，mRNA上m⁶A的可逆性修饰与其调节蛋白的发现，使人们开始认识到表观转录调控的重要作用；然而，在目前已知的一百余种RNA化学修饰中，除了m⁶A等少数几种修饰受到相对广泛的研究，此外还有数目众多的RNA修饰在调节神经发育过程中的功能完全未知。深入探究这些表观转录组调控机制如何影响神经发育与脑发育疾病发生，将深化人们对表观转录组与神经发育之间关系的理解，并为相关疾病的诊疗提供新思路。

本实验室将以小鼠模型与人脑类器官模型研究神经发育的表观转录组调控机制与神经发育疾病的致病机制。首先实验室前期已经构建了人脑类器官病毒感染系统与细胞分化GFP报告系统，将进行RNA修饰相关基因的慢病毒无偏差CRISPR敲除筛选与进行智力低下、小颅畸形等疾病相关的RNA修饰基因的逆转录病毒敲降筛选，寻找重要的新基因与新修饰。长期将与南大附属医院等合作，深入挖掘相关脑发育疾病的新发基因突变，并利用建立的实验平台，阐明其致病机制、探索潜在的治疗手段。

非常欢迎感兴趣的同学加入本实验室。本实验室招收硕士研究生、博士研究生、博士后及副研究员等，有意向者请发邮件至feng.zhang@nju.edu.cn 

发表文章 (* 代表第一或共一文章)

第一或共一文章：

1. Zhang, F.*, Fu, Y., Jimenez-Cyrus, D., Zhao, T., Shen, Y., Sun, Y., Zhang, Z., Wang, Q., Kawaguchi, R., Geschwind, D.H., He C., Ming, G.L., and Song, H. (2024). m(6)A/YTHDF2-mediated mRNA decay targets TGF-beta signaling to suppress the quiescence acquisition of early postnatal mouse hippocampal NSCs. Cell Stem Cell. 10.1016/j.stem.2024.10.002.

2.Zhang, F.*, Yoon, K., Zhang, D.Y., Kim, N.S., Ming, G.L., and Song, H. (2023). Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m(3)C modification. Cell Stem Cell 30, 300-311 e311. 10.1016/j.stem.2023.01.007.

3.Zhang, F.*, Yoon, K., Kim, N., Ming, G., and Song, H. (2023) Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus. Stem Cell Reports, 18, 1468-1481. https://doi.org/10.1016/j.stemcr.2023.05.021.

4.Zhang, F.*, Ignatova, V.V.*, Ming, G.L., and Song, H. (2023). Advances in brain epitranscriptomics research and translational opportunities. Mol Psychiatry. 10.1038/s41380-023-02339-x.

5.Zhang, F.*, Wang, Y.*, Wang, T., Yao, L., Lam, S.M., Huang, X., Fan, J., Wang, Q., Liu, L., Jiang, Y., Zhang, H., Shi, L., Yu, M., Shui, G., Wang, Y., Gao, F., Zhang, X. and Xu, Z. (2018). cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development. Proceedings of the National Academy of Sciences 115, E9449-E9458.

6.Yuan, L.*, Huang, X.Y.*, Liu, Z.Y.*, Zhang, F.*, Zhu, X.L.*, Yu, J.Y.*, Ji, X., Xu, Y.P., Li, G., Li, C.,Wang, H. J., Deng, Y. Q., Wu, M., Cheng, M. L., Ye, Q., Xie, D. Y., Li, X. F., Wang, X., Shi, W., Hu, B., Shi, P. Y., Xu, Z. and Qin, C. F. (2017). A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. Science 358, 933-936.

7.Zhang, F.*, Wang, H.*, Wang, Q.*, Liu, Z.*, Yuan, L.*, Huang, X.*, Li, G., Ye, Q., Yang, H., Shi, L., Deng, Y. Q., Qin, C. F. and Xu, Z.(2017). American Strain of Zika Virus Causes More Severe Microcephaly than an Old Asian Strain in neonatal Mice. Ebiomedicine25, 95-105.

8.Zhang, F.*, Yu, J., Yang, T., Xu, D., Chi, Z., Xia, Y., and Xu, Z. (2016). A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development. Journal of Biology Chemistry 291, 11466-11475. (Cover story with editorial comments & highlight)

9.Zhang, F.*, Xu, D., Yuan, L., Sun, Y., and Xu, Z. (2014). Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance. Nature Communications 5, 5815.

10.Yu, J.*, Zhang, F.*, Wang, S., Zhang, Y., Fan, M., and Xu, Z. (2014). TAK1 is activated by TGF-beta signaling and controls axonal growth during brain development. Journal of Molecular Cell Biology 6, 349-351.

其他文章：

1.      Sun, Y.*, Wang, X.*, Zhang, D.Y., Zhang, Z., Bhattarai, J.P., Wang, Y., Park, K.H., Dong, W., Hung, Y.F., Yang, Q., Zhang, F., Rajamani, K., et al. (2025). Brain-wide neuronal circuit connectome of human glioblastoma. Nature. 10.1038/s41586-025-08634-7.

2.     Shen, Y., Wong, S.Z.H., Ma, T., Zhang, F., Wang, Q., Kawaguchi, R., Geschwind, D.H., Wang, J., He, C., Ming, G.L., and Song, H. (2025). m(6)A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice. Cell Stem Cell. 10.1016/j.stem.2025.02.011

3.     Muneer, A.*, Wang, L.*, Xie, L.*, Zhang, F., Wu, B., Mei, L., Lenarcic, E.M., Feng, E.H., Song, J., Xiong, Y., Yu, X., Wang, C., Jain, K., Strahl, B. D., Cook, J. G., Wan, Y. Y., Moorman, N. J., Song, H., Jin, J. and Chen, X. (2023). Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation. Cell Chem Biol. 10.1016/j.chembiol.2023.09.012.

4.     Yao, M.*, Meng, M., Yang, X., Wang, S., Zhang, H., Zhang, F., Shi, L., Zhang, Y., Zhang, X., and Xu, Z. (2022). POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function. Cell Rep39, 110642. 10.1016/j.celrep.2022.110642.

5.     Ma, T.*, Zhang, F., Wang, Y., Xu, Z. (2022) Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions. Journal of Genetics and Genomics 49 (6), 519-522

6.     Huang, W.*, Wong, S.*, Pather, S.*, Nguyen, P., Zhang, F., Zhang, D., Zhang, Z., Lu, L., Fang, W., Chen, L., Fernandes, A., Su, Y., Song, H. and Ming, G. L. (2021). Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells. Cell Stem Cell 28 (9), 1657-1670. e10

7.     Jacob, F*, Pather, S., Huang, W. Zhang, F., Wong, S., Zhou, H., Cubitt, B., Fan, W., Chen, C. Z., Xu, M., Pradhan, M., Zhang, D. Y., Zheng, W., Bang, A. G., Song, H., Carlos de la Torre, J. and Ming, G. L. (2020). Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium. Cell Stem Cell 27 (6), 937-950. e9

8.     Chang, Y.*, Jiang, Y.*, Li, C., Wang, Q., Zhang, F., Qin, C., Wu, Q., Li, J., Xu, Z. (2020). Different gene networks are disturbed by Zika virus infection in a mouse microcephaly model. Genomics, Proteomics & Bioinformatics 18 (6), 737-748

9.     Shi, H.*, Zhang, X.*, Weng, Y.*, Lu, Z., Liu, Y., Lu, Z., Li, J., Hao, P., Zhang, Y., Zhang, F., Wu, Y., Delgado, J. Y., Su, Y., Patel, M. J., Cao, X., Shen, B., Huang, X., Ming, G. L., Zhuang, X., Song, H., He, C. and Zhou, T. (2018). m⁶A facilitates hippocampus-dependent learning and memory through YTHDF1. Nature 563 (7730), 249-253

10.  Xu, D.*, Yao, M.*, Wang, Y.*, Yuan, L.*, Hoeck, J.D.*, Yu, J., Liu, L., Yeap, Y.Y.C., Zhang, W., Zhang, F., Feng, Y., Ma, T., Wang, Y., Ng, D. C. H., Niu, X., Su, B., Behrens, A. and Xu, Z. (2018). MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. PLoS Biology 16, e2006613.

11.  Fan, J.*, Wang, Y.*, Liu, L., Zhang, H., Zhang, F., Shi, L., Yu, M., Gao, F., and Xu, Z. (2017). cTAGE5 deletion in pancreatic beta cells impairs proinsulin trafficking and insulin biogenesis in mice.Journal of Cell Biology 216, 4153-4164.

12.  Wang, Y.*, Liu, L.*, Zhang, H., Fan, J., Zhang, F., Yu, M., Shi, L., Yang, L., Lam, S.M., Wang, H., Chen, X., Wang, Y., Gao, F., Shui, G. and Xu, Z. (2016). Mea6 controls VLDL transport through the coordinated regulation of COPII assembly. Cell Research 26, 787-804.

13.  Zhang, L.*, Zhang, F., Yang, T., Zhu, X., Zheng, N., Li, H., Zhu, D., Zhu, Y., and Xu, Z. (2016). The B-cell receptor BR3 modulates cellular branching via Rac1 during neuronal migration.Journal of Molecular Cell Biology 8, 363-365.

14.  Liu, B.*, Ma, A., Zhang, F., Wang, Y., Li, Z., Li, Q., Xu, Z., and Zheng, Y. (2016). MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Scientific Reports 6, 21534.

15.  Xu, D.*, Zhang, F., Wang, Y., Sun, Y., and Xu, Z. (2014). Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Cell Reports 6, 104-116.

16.  Yang, T.*, Sun, Y., Zhang, F., Zhu, Y., Shi, L., Li, H., and Xu, Z. (2012). POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration. Cell Reports2, 640-651.

17.  Sun, Y.*, Fei, T.*, Yang, T.*, Zhang, F., Chen, Y.G., Li, H., and Xu, Z. (2010). The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development. Journal of Biological Chemistry285, 39039-39050.

Google Scholar link:https://scholar.google.com/citations?user=W2t5HpUAAAAJ&hl=zh-CN&oi=sra

中国科学院大学优秀毕业生(2017)

中国科学院院长优秀奖学金(2017)

恒源祥英才二等奖(2015)

中国科学院遗传发育所益海嘉里奖学金(2015)

中国科学院宝洁优秀研究生奖学金(2015)

博士研究生国家奖学金(2014)

山东大学潍柴动力奖学金(2009)