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赵权 教授

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办公地址：

电子邮件： qzhao@nju.edu.cn

个人主页：

  • 个人简介
  • 科研成果
  • 获奖情况

个人简介

       赵权，南京大学生命科学学院教授、博士生导师，入选教育部“新世纪优秀人才支持计划”、江苏省“333 高层次人才培养工程” 第二层次人才。1988 年毕业于南京大学生物化学系，获理学学士学位；2002 年毕业于澳大利亚墨尔本La Trobe University生物化学系，获博士学位。2006年入职南京大学生命科学学院，长期致力于基因转录与表观遗传调控机制研究。以通讯作者在Nature Structural & Molecular Biology、Nature Communications、Blood、Nucleic Acids Research、Cell Death & Differentiation、Genome Medicine、Cancer Research、Journal of Biological Chemistry等国际权威期刊发表系列研究成果。作为项目创始人，牵头研发1 类抗肿瘤靶向创新药 CA1257，已获美国 FDA与中国 NMPA临床试验（IND）批准，正在开展实体瘤临床研究。



研究方向

研究方向：

1. 基因转录及表观遗传学调控机制；

2. 癌症的发生机理与防治研究

主要研究介绍：

    基因表达调控是生命活动的核心机制。表观遗传调控（包括组蛋白修饰、DNA 修饰等）作为基因表达的关键调控方式，深度参与细胞命运决定，已成为生命科学领域发展迅速的前沿方向。

    本课题组聚焦基因转录与表观遗传调控，系统解析生物大分子的修饰特征、新型分子识别机制及其生理病理功能。研究重点围绕肺癌、结直肠癌、乳腺癌、胃癌、脑胶质瘤、黑色素瘤、白血病等恶性肿瘤，以及血红蛋白病等遗传性血液病，阐明疾病发生发展的关键分子事件，揭示细胞内外信号对基因表达的时空调控规律，阐释肿瘤恶性增殖、异常分化、侵袭转移及细胞重编程的核心机理，为重大疾病的个体化精准治疗提供新靶点与新策略。在此基础上，课题组进一步开展创新药物研发与临床转化研究，推动基础研究成果向临床应用落地。


学术兼职

中国生物化学与分子生物学学会理事;

江苏省生物化学与分子生物学学会副理事长

工作经历

科研成果

    代表性论文：

1. Li Q, Ci H, Zhao P, Yang D, Zou Y, Chen P, Wu D, Shangguan W, Li W, Meng X, Xing M, Chen Y, Zhang M, Chen B, Kong L, Zen K, Huang DCS, Jiang ZW*, Zhao Q*. NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis. J Exp Clin Cancer Res. 2025;44(1):90. (*Corresponding author)

2．Xu J, Dong X, Peng Y, Yan J, Xu P, Li F, Zhang S, Chen L, Meng X, Wang K, Xing M, Li W, Huang DCS, Zhao Q*, Chen B*. ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways. Adv Sci. 2025;12(20):e2409219.

3.  Xing M, Yao B; Xu J, Lu P, Li Q, Wu D, Chen B, Wei J, Su L, Zhao Q*. NatD epigenetically activates FOXA2 expression to promote breast cancer progression by facilitating MMP14 expression. iScience, 2024, 27(2):108840.

4.Yang D, Li Q, Lu P, Wu D, Li W, Meng X, Xing M, Shangguan W, Chen B, Yang J, Zhang Z, Wang Z, Huang DCS, Zhao Q*. FOXA2 activates HIF2α expression to promote tumor progression and is regulated by the E3 ubiquitin ligase VHL in renal cell carcinoma. J Biol Chem , 2024, 300(1):105535. 

5.Zeng X, Yao B, Liu J, Gong GW, Liu M, Li J, Pan HF, Li Q, Yang D, Lu P, Wu D, Xu P, Chen B, Chen P, Zhang M, Zen K, Jing J, Huang DCS, Chen D, Jiang ZW, Zhao Q*. The SMARCA4-R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer. NPJ Precis Oncol. 2023,7(1):28.

6.Li X, Chen M, Liu B, Lu P, Lv X, Zhao X, Cui S, Xu P, Nakamura Y, Kurita R, Chen B, Huang DCS, Liu DP, Liu M, Zhao Q*. Transcriptional silencing of fetal hemoglobin expression by NonO. Nucleic Acids Res. 2021,49(17):9711-9723.

7.Gui T, Liu M, Yao B, Jiang H, Yang D, Li Q, Zeng X, Wang Y, Cao J, Deng Y, Li X, Xu P, Zhou L, Li D, Wang Z, Zen K, Huang DCS, Chen B, Wan G, Zhao Q*. TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer. Cell Death Differ. 2021, 28(12):3316-3328

8. Yao B, Gui T, Zeng X, Deng Y, Wang Z, Wang Y, Yang D, Li Q, Xu P, Hu R, Li X, Chen B, Wang J, Zen K, Li H, Davis MJ, Herold MJ, Pan HF, Jiang ZW, Huang DCS, Liu M, Ju J, Zhao Q*. PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling. Genome Med. 2021,13(1):58

9.Wang Y, Li X, Ge J, Liu M, Pang X, Liu J, Luo C, Xu Y, Zhao Q*. The methyltransferase PRMT1 regulates γ-globin translation. J Biol Chem. 2021, 296:100417

10.Liu M, Yao B, Gui T, Guo C, Wu X, Li J, Ma L, Deng Y, Xu P, Wang Y, Yang D, Li Q, Zeng X, Li X, Hu R, Ge J, Yu Z, Chen Y, Chen B, Ju J, Zhao Q*. PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression. Theranostics. 2020,10(10): 4437–4452.

11.Nie M, Wang Y, Guo C, Li X, Wang Y, Deng Y, Yao B, Gui T, Ma C, Liu M, Wang P, Wang R, Tan R, Fang M, Chen B, He Y, Huang DCS, Ju J, Zhao Q*. CARM1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells. J Biol Chem. 2018, 293(45):17454-17463.

12.Ju J, Zhao Q*. Regulation of γ-globin gene expression and its clinical applications.Yi Chuan (Hereditas). 2018,40(6):429-444. (Invited Review)

13.Ju J, Chen A, Deng Y, Liu M, Wang Y, Wang Y, Nie M, Wang C, Ding H, Yao B, Gui T, Li X, Xu Z, Ma C, Song Y, Kvansakul M, Zen K, Zhang CY, Luo C, Fang M, Huang DCS, Allis CD, Tan R, Zeng CK, Wei J, Zhao Q*. NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression. Nat Commun. 2017,8(1):928.

14.Wang Y, Wang Y, Ma L, Nie M, Ju J, Liu M, Deng Y, Yao B, Gui T, Li X, Guo C, Ma C, Tan R, Zhao Q*. Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ϵ-Globin Gene Expression. J Biol Chem. 2017,292(12):4811-4817.

15.Wang Y, Rank G, Li Z, Wang Y, Ju J, Nuber A, Wu Y, Liu M, Nie M, Huang F, Cerruti L, Ma C, Tan R, Schotta G, Jane SM, Zeng CK, Zhao Q*. ϵ-globin expression is regulated by SUV4-20h1. Haematologica. 2016,101(5):e168-72.

16.Liu M, Huang F, Zhang D, Ju J, Wu XB, Wang Y, Wang Y, Wu Y, Nie M, Li Z, Ma C, Chen X, Zhou JY, Tan R, Yang BL, Zen K, Zhang CY, Chen YG, Zhao Q*. Heterochromatin Protein HP1γ Promotes Colorectal Cancer Progression and Is Regulated by miR-30a. Cancer Res. 2015, 75(21): 4593-604.

17.Ju J, Wang Y, Liu R, Zhang Y, Xu Z, Wang Y, Wu Y, Liu M, Cerruti L, Zou F, Ma C, Fang M, Tan R, Jane SM, Zhao Q*. Human fetal globin gene expression is regulated by LYAR. Nucleic Acids Res. 2014, 42(15):9740-52.

18.Xu Z, He Y, Ju J, Rank G, Cerruti L, Ma C, Simpson R, Moritz R, Jane S, Zhao Q*. The role of WDR5 in silencing human fetal globin gene expression. Haematologica.  2012, 97(11), 1632-40.

19.Rank G, Cerruti L, Moritz RL, Simpson RJ, Jane SM, Zhao Q*. Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression. Blood. 2010, 116(9):1585-92.

20.Zhao Q*, Rank G, Tan YT, Li H, Moritz RL, Simpson RJ, Cerruti L, Curtis DJ, Patel DJ, Allis CD, Cunningham JM, Jane SM. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol. 2009, 16(3):304-11.

21. Darido C, Georgy SR, Wilanowski T, Dworkin S, Auden A, Zhao Q, Rank G, Srivastava S, Finlay MJ, Papenfuss AT, Pandolfi PP, Pearson RB, Jane SM*. Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis. Cancer Cell. 2011, 20(5):635-48.

22.Caddy J, Wilanowski T, Darido C, Dworkin S, Ting SB, Zhao Q, Rank G, Auden A, Srivastava S, Papenfuss TA, Murdoch JN, Humbert PO, Boulos N, Weber T, Zuo J, Cunningham JM, Jane SM*. Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell. 2010, 19(1):138-47.

23.Zhao Q, Zhou WL, Rank G, Sutton R, Wang X, Cumming H, Cerruti L, Cunningham JM, and Jane SM*. Repression of human {gamma}-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter. Blood. 2006, 107 (5):2138-45.

24. Zhao Q, Cumming H, Cerruti L, Cunningham JM, Jane SM*. Site-specific Acetylation of the Fetal Globin Activator NF-E4 Prevents Its Ubiquitination and Regulates Its Interaction with the Histone Deacetylase, HDAC1. J Biol Chem. 2004, 279(40):41477-86.

25. Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT, Hoogenraad NJ*. A mitochondrial specific stress response in mammalian cells. EMBO J. 2002, 21(17):4411-9.


获奖情况

江苏省“333高层次人才培养工程”第二层次人才（2013）

南京领军型科技创业人才（2012）

南京大学“优秀中青年学科带头人”（2008）

教育部“新世纪优秀人才支持计划”（2007）

Cooley's Anemia Foundation Research Fellowship, USA （2006-2008）

江苏省科学技术进步二等奖（1999）